The free energy landscapes governing conformational changes in a glutamate receptor ligand-binding domain
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Functional insights from glutamate receptor ion channel structuresEmerging models of glutamate receptor ion channel structure and functionComputational study of synthetic agonist ligands of ionotropic glutamate receptorsMechanisms of Antagonism of the GluR2 AMPA Receptor: Structure and Dynamics of the Complex of Two Willardiine Antagonists with the Glutamate Binding DomainBinding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonistsA Conformational Intermediate in Glutamate Receptor ActivationConformational Analysis of NMDA Receptor GluN1, GluN2, and GluN3 Ligand-Binding Domains Reveals Subtype-Specific CharacteristicsGlutamate receptor ion channels: structure, regulation, and functionP-loop conformation governed crizotinib resistance in G2032R-mutated ROS1 tyrosine kinase: clues from free energy landscapeGluN1-specific redox effects on the kinetic mechanism of NMDA receptor activationGlutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain.Role of the Ion Channel Extracellular Collar in AMPA Receptor GatingIntrinsic dynamics of restriction endonuclease EcoO109I studied by molecular dynamics simulations and X-ray scattering data analysis.Energetics of the cleft closing transition and the role of electrostatic interactions in conformational rearrangements of the glutamate receptor ligand binding domain.Molecular mechanism of the sweet taste enhancers.On the mechanisms of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor binding to glutamate and kainate.Exploring kainate receptor pharmacology using molecular dynamics simulations.Structural mechanism of N-methyl-D-aspartate receptor type 1 partial agonismCharacterization of proteins with wide-angle X-ray solution scattering (WAXS)The hidden energetics of ligand binding and activation in a glutamate receptorStructural landscape of isolated agonist-binding domains from single AMPA receptorsReduced curvature of ligand-binding domain free-energy surface underlies partial agonism at NMDA receptors.X-ray solution scattering studies of the structural diversity intrinsic to protein ensemblesLigand photo-isomerization triggers conformational changes in iGluR2 ligand binding domainStructural Determinants for the Binding of Morphinan Agonists to the μ-Opioid ReceptorConformational transitions in the glycine-bound GluN1 NMDA receptor LBD via single-molecule FRET.Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR.A rapid coarse residue-based computational method for x-ray solution scattering characterization of protein folds and multiple conformational states of large protein complexes.Selectivity and cooperativity of modulatory ions in a neurotransmitter receptorComputations of standard binding free energies with molecular dynamics simulations.Mechanism of partial agonism at the GluR2 AMPA receptor: Measurements of lobe orientation in solution.Molecular lock regulates binding of glycine to a primitive NMDA receptor.Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation.Structure and gating of tetrameric glutamate receptors.Retour aux sources: defining the structural basis of glutamate receptor activation.Validation of Molecular Simulation: An Overview of Issues.Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.AMPA receptor ligand binding domain mobility revealed by functional cross linking.Reaction pathway and free energy profile for prechemical reaction step of human butyrylcholinesterase-catalyzed hydrolysis of (-)-cocaine by combined targeted molecular dynamics and potential of mean force simulations.Gating motions underlie AMPA receptor secretion from the endoplasmic reticulum.
P2860
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P2860
The free energy landscapes governing conformational changes in a glutamate receptor ligand-binding domain
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The free energy landscapes gov ...... receptor ligand-binding domain
@ast
The free energy landscapes gov ...... receptor ligand-binding domain
@en
type
label
The free energy landscapes gov ...... receptor ligand-binding domain
@ast
The free energy landscapes gov ...... receptor ligand-binding domain
@en
prefLabel
The free energy landscapes gov ...... receptor ligand-binding domain
@ast
The free energy landscapes gov ...... receptor ligand-binding domain
@en
P2860
P1433
P1476
The free energy landscapes gov ...... receptor ligand-binding domain
@en
P2093
Benoît Roux
P2860
P304
P356
10.1016/J.STR.2007.07.015
P577
2007-10-01T00:00:00Z