Mutagenesis of the human transferrin receptor: two cytoplasmic phenylalanines are required for efficient internalization and a second-site mutation is capable of reverting an internalization-defective phenotype.
about
The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cellsCholesterol-dependent retention of GPI-anchored proteins in endosomes.Association of human transferrin receptor with GABARAP.ARFGAP1 promotes AP-2-dependent endocytosis.Phagocytic chimeric receptors require both transmembrane and cytoplasmic domains from the mannose receptor.Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow processThe amino terminus of GLUT4 functions as an internalization motif but not an intracellular retention signal when substituted for the transferrin receptor cytoplasmic domainApical and basolateral coated pits of MDCK cells differ in their rates of maturation into coated vesicles, but not in the ability to distinguish between mutant hemagglutinin proteins with different internalization signals.Transferrin receptor containing the SDYQRL motif of TGN38 causes a reorganization of the recycling compartment but is not targeted to the TGNEvidence from lateral mobility studies for dynamic interactions of a mutant influenza hemagglutinin with coated pits.The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.Membrane protein sorting in the yeast secretory pathway: evidence that the vacuole may be the default compartment.Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif.The paramyxovirus simian virus 5 hemagglutinin-neuraminidase glycoprotein, but not the fusion glycoprotein, is internalized via coated pits and enters the endocytic pathway.Human muscarinic cholinergic receptor Hm1 internalizes via clathrin-coated vesicles.Overexpression of proteins containing tyrosine- or leucine-based sorting signals affects transferrin receptor trafficking.Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor.Effects of overexpression of the transferrin receptor on the rates of transferrin recycling and uptake of non-transferrin-bound iron.Effects of second intracellular loop mutations on signal transduction and internalization of the gonadotropin-releasing hormone receptor.Newly synthesized transferrin receptors can be detected in the endosome before they appear on the cell surface.Constitutive internalization of cystic fibrosis transmembrane conductance regulator occurs via clathrin-dependent endocytosis and is regulated by protein phosphorylation.Clathrin and HA2 adaptors: effects of potassium depletion, hypertonic medium, and cytosol acidification.Degradation of mutant influenza virus hemagglutinins is influenced by cytoplasmic sequences independent of internalization signals.The transferrin receptor cytoplasmic domain determines its rate of transport through the biosynthetic pathway and its susceptibility to cleavage early in the pathway.
P2860
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P2860
Mutagenesis of the human transferrin receptor: two cytoplasmic phenylalanines are required for efficient internalization and a second-site mutation is capable of reverting an internalization-defective phenotype.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Mutagenesis of the human trans ...... alization-defective phenotype.
@ast
Mutagenesis of the human trans ...... alization-defective phenotype.
@en
type
label
Mutagenesis of the human trans ...... alization-defective phenotype.
@ast
Mutagenesis of the human trans ...... alization-defective phenotype.
@en
prefLabel
Mutagenesis of the human trans ...... alization-defective phenotype.
@ast
Mutagenesis of the human trans ...... alization-defective phenotype.
@en
P2093
P2860
P356
P1476
Mutagenesis of the human trans ...... alization-defective phenotype.
@en
P2093
P2860
P304
P356
10.1083/JCB.112.5.853
P407
P577
1991-03-01T00:00:00Z