The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.
about
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advancesKinase activation through dimerization by human SH2-BIdentification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding.Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptorEndocytic properties of the M-type 180-kDa receptor for secretory phospholipases A2Tyrosine 569 in the c-Fms juxtamembrane domain is essential for kinase activity and macrophage colony-stimulating factor-dependent internalizationEpsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis.Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathwaysLigand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins.Recruitment of epidermal growth factor and transferrin receptors into coated pits in vitro: differing biochemical requirements.Specific factors are required for kinase-dependent endocytosis of insulin receptors.Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain.In vitro binding of clathrin adaptors to sorting signals correlates with endocytosis and basolateral sorting.Two steps of insulin receptor internalization depend on different domains of the beta-subunit.Mutational and secondary structural analysis of the basolateral sorting signal of the polymeric immunoglobulin receptor.The sequence NPFXD defines a new class of endocytosis signal in Saccharomyces cerevisiae.Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobilityInsulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif.Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking.The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.Insulin receptor kinase activation releases a constraint maintaining the receptor on microvilli.Endocytosis of receptor tyrosine kinasesSpecificity of LIM domain interactions with receptor tyrosine kinases.Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism.Molecular and cellular biology of insulin-receptor internalization.The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.Overexpression of proteins containing tyrosine- or leucine-based sorting signals affects transferrin receptor trafficking.Partitioning of proteins into plasma membrane microdomains. Clustering of mutant influenza virus hemagglutinins into coated pits depends on the strength of the internalization signal.Identification of three internalization sequences in the cytoplasmic tail of the 46 kDa mannose 6-phosphate receptor.Dynamic or stable interactions of influenza hemagglutinin mutants with coated pits. Dependence on the internalization signal but not on aggregation.Roles for a cytoplasmic tyrosine and tyrosine kinase activity in the interactions of Neu receptors with coated pits.Regulation of targeting signals in membrane proteins. [review]The processing of ligands by the class A scavenger receptor is dependent on signal information located in the cytoplasmic domain.Dual role of a dileucine motif in insulin receptor endocytosis.Mutation of tyrosine 960 within the insulin receptor juxtamembrane domain impairs glucose transport but does not inhibit ligand-mediated phosphorylation of insulin receptor substrate-2 in 3T3-L1 adipocytes.PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.Role of two dileucine-like motifs in insulin receptor anchoring to microvilli.Saturation of the endocytic pathway for the transferrin receptor does not affect the endocytosis of the epidermal growth factor receptor.In vitro binding and phosphorylation of insulin receptor substrate 1 by the insulin receptor. Role of interactions mediated by the phosphotyrosine-binding domain and the pleckstrin-homology domain.
P2860
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P2860
The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
The insulin receptor juxtamemb ...... -turn internalization signals.
@ast
The insulin receptor juxtamemb ...... -turn internalization signals.
@en
type
label
The insulin receptor juxtamemb ...... -turn internalization signals.
@ast
The insulin receptor juxtamemb ...... -turn internalization signals.
@en
prefLabel
The insulin receptor juxtamemb ...... -turn internalization signals.
@ast
The insulin receptor juxtamemb ...... -turn internalization signals.
@en
P2093
P2860
P356
P1476
The insulin receptor juxtamemb ...... -turn internalization signals.
@en
P2093
D C Cahill
J M Backer
R B Cheatham
S E Shoelson
P2860
P304
P356
10.1083/JCB.118.4.831
P407
P577
1992-08-01T00:00:00Z