PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.
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Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advancesLandmarks in insulin researchCloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting proteinInsulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteinsEpidermal growth factor directs sex-specific steroid signaling through Src activationMolecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sitesHuman GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domainsThe phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor proteinKinase activation through dimerization by human SH2-BCytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalinTyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migrationSequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domainIntegrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signalingCrystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1Multiple modes of peptide recognition by the PTB domain of the cell fate determinant NumbCrystal structures of the Dab homology domains of mouse disabled 1 and 2Structural basis for the specific recognition of RET by the Dok1 phosphotyrosine binding domainCrystal structure of the human Fe65-PTB1 domainStructural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domainStructure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificityShc and CEACAM1 interact to regulate the mitogenic action of insulinThe signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiationRe-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domainSignalling scaffolds and local organization of cellular behaviourInteraction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor proteinInsulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src)A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cellsInsulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signalingFunctional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptorsSrc homology 3 domain-dependent interaction of Nck-2 with insulin receptor substrate-1The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNXEvidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptorEvidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signalingDomain-dependent function of the rasGAP-binding protein p62Dok in cell signaling.The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistanceThe role of G proteins in insulin signalling.Evolution of the vertebrate insulin receptor substrate (Irs) gene family
P2860
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P2860
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.
@en
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.
@nl
type
label
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.
@en
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.
@nl
prefLabel
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.
@en
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.
@nl
P2093
P2860
P356
P1476
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.
@en
P2093
Groninga L
Miyazaki M
Ottinger E
Shoelson SE
P2860
P304
27407-27410
P356
10.1074/JBC.270.46.27407
P407
P577
1995-11-01T00:00:00Z