Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality.
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Animal models of hemophiliaLessons Learned from Animal Models of Inherited Bleeding Disorders.The role of tissue factor and factor VIIa in hemostasis.Long-term expression of canine FVIIa in hemophilic dogsA zymogen-like factor Xa variant corrects the coagulation defect in hemophiliaProtein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency.Employing a gain-of-function factor IX variant R338L to advance the efficacy and safety of hemophilia B human gene therapy: preclinical evaluation supporting an ongoing adeno-associated virus clinical trial.Engineering Factor Viii for Hemophilia Gene Therapy.Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia.Successful treatment of canine hemophilia by continuous expression of canine FVIIa.Nanocapsule-delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice.Pharmacokinetics, pharmacodynamics and safety of recombinant canine FVIIa in a study dosing one haemophilia A and one haemostatically normal dog.FVIIa as used pharmacologically is not TF dependent in hemophilia B miceGene therapy for haemophilia: a long and winding road.Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo.Animal models of FVIIa gene expression: their role in the future development of haemophilia treatmentGene Delivery of Activated Factor VII Using Alternative Adeno-Associated Virus Serotype Improves Hemostasis in Hemophiliac Mice with FVIII Inhibitors and Adeno-Associated Virus Neutralizing Antibodies.Factor X Friuli Coagulation Disorder.The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo.Targeting factor VIII expression to platelets for hemophilia A gene therapy does not induce an apparent thrombotic risk in mice.Characterization of canine coagulation factor VII and its complex formation with tissue factor: canine-human cross-species compatibility.
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Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality.
description
2008 nî lūn-bûn
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2008年の論文
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2008年論文
@yue
2008年論文
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2008年論文
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2008年論文
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name
Long-term expression of murine ...... els cause premature mortality.
@ast
Long-term expression of murine ...... els cause premature mortality.
@en
type
label
Long-term expression of murine ...... els cause premature mortality.
@ast
Long-term expression of murine ...... els cause premature mortality.
@en
prefLabel
Long-term expression of murine ...... els cause premature mortality.
@ast
Long-term expression of murine ...... els cause premature mortality.
@en
P2093
P2860
P356
P1476
Long-term expression of murine ...... els cause premature mortality.
@en
P2093
Alexander Schlachterman
Katherine A High
Majed N Aljamali
Paris Margaritis
Ralph Bunte
Rodney M Camire
Shing Jen Tai
P2860
P304
P356
10.1172/JCI32878
P407
P577
2008-05-01T00:00:00Z