about
Molecular mechanism of action of metformin: old or new insights?Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cellsThe AMPK signalling pathway coordinates cell growth, autophagy and metabolismFrom the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinaseAMPK activators: mechanisms of action and physiological activitiesLinking Mitochondria to Synapses: New Insights for Stress-Related Neuropsychiatric DisordersNew mechanisms of metformin action: Focusing on mitochondria and the gutAMP deaminase 1 gene polymorphism and heart disease-a genetic association that highlights new treatmentAMPK as a potential anticancer target - friend or foe?Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the EndotheliumEffects of fatty acid treatments on the dexamethasone-induced intramuscular lipid accumulation in chickensA conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulationThe Snf1 kinase and proteasome-associated Rad23 regulate UV-responsive gene expression.Roles of the Snf1-activating kinases during nitrogen limitation and pseudohyphal differentiation in Saccharomyces cerevisiae.Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and PerspectivesMetabolic shifts during aging and pathologyDifferential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagyAcute inhibition of selected membrane-proximal mouse T cell receptor signaling by mitochondrial antagonistsA novel flow cytometric high throughput assay for a systematic study on molecular mechanisms underlying T cell receptor-mediated integrin activationAMP-activated protein kinase plays an important evolutionary conserved role in the regulation of glucose metabolism in fish skeletal muscle cellsActivation of AMP-activated protein kinase by 3,3'-Diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivoApoptotic efficacy of etomoxir in human acute myeloid leukemia cells. Cooperation with arsenic trioxide and glycolytic inhibitors, and regulation by oxidative stress and protein kinase activitiesPiperine Induces Hepatic Low-Density Lipoprotein Receptor Expression through Proteolytic Activation of Sterol Regulatory Element-Binding ProteinsThe metabolic consequences of hepatic AMP-kinase phosphorylation in rainbow troutThe LKB1-AMPK pathway: metabolism and growth control in tumour suppressionPioglitazone enhances mitochondrial biogenesis and ribosomal protein biosynthesis in skeletal muscle in polycystic ovary syndrome.High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db miceHuman resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injuryDevelopment of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators.Classification of protein kinases on the basis of both kinase and non-kinase regionsBeta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2.Insights into the molecular mechanism of glucose metabolism regulation under stress in chicken skeletal muscle tissues.Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase.Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancerMetformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.The dynamical mechanism of auto-inhibition of AMP-activated protein kinaseReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK.Radiosensitization of pancreatic cancer cells by metformin through the AMPK pathway.AMPK regulates metabolic actions of glucocorticoids by phosphorylating the glucocorticoid receptor through p38 MAPKAMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
AMP-activated protein kinase as a drug target.
@ast
AMP-activated protein kinase as a drug target.
@en
type
label
AMP-activated protein kinase as a drug target.
@ast
AMP-activated protein kinase as a drug target.
@en
prefLabel
AMP-activated protein kinase as a drug target.
@ast
AMP-activated protein kinase as a drug target.
@en
P1476
AMP-activated protein kinase as a drug target
@en
P2093
D Grahame Hardie
P304
P356
10.1146/ANNUREV.PHARMTOX.47.120505.105304
P577
2007-01-01T00:00:00Z