The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k.
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The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylationPhosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivoS6K1 plays a critical role in early adipocyte differentiationRegulation of 4E-BP1 phosphorylation: a novel two-step mechanismS6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathwayTime-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cellsModulation of T Cell Metabolism and Function through Calcium SignalingEap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae.TORC1 promotes phosphorylation of ribosomal protein S6 via the AGC kinase Ypk3 in Saccharomyces cerevisiaeHierarchical phosphorylation of the translation inhibitor 4E-BP1Insulin promotes glucose consumption via regulation of miR-99a/mTOR/PKM2 pathwayInsulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTOR) signalling is impaired by the presence of hydrogen peroxideTuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathwayThe rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin.Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancerTranslational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities.Disruption of genes encoding eIF4E binding proteins-1 and -2 does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice.Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.Avian reovirus nonstructural protein p17-induced G(2)/M cell cycle arrest and host cellular protein translation shutoff involve activation of p53-dependent pathways.Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4EA heat-sensitive Arabidopsis thaliana kinase substitutes for human p70s6k function in vivo.Motility, survival, and proliferation.mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cellsCoffin-Lowry syndrome: clinical and molecular features.Predictive value of phosphorylated mammalian target of rapamycin for disease-free survival in breast cancer patients receiving neoadjuvant chemotherapy.AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activityAnti-Inflammatory Action of Insulin via Induction of Gadd45-β Transcription by the mTOR Signaling Pathway.Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer.Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome.Drosophila S6 Kinase like inhibits neuromuscular junction growth by downregulating the BMP receptor thickveins.Gene expression profiling in pachyonychia congenita skinRoles of the immune system in skin cancer.The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signalingStimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytesTargeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity.Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis.The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae.
P2860
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P2860
The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
The insulin-induced signalling ...... mmediately upstream of p70s6k.
@ast
The insulin-induced signalling ...... mmediately upstream of p70s6k.
@en
type
label
The insulin-induced signalling ...... mmediately upstream of p70s6k.
@ast
The insulin-induced signalling ...... mmediately upstream of p70s6k.
@en
prefLabel
The insulin-induced signalling ...... mmediately upstream of p70s6k.
@ast
The insulin-induced signalling ...... mmediately upstream of p70s6k.
@en
P2093
P2860
P1476
The insulin-induced signalling ...... mmediately upstream of p70s6k.
@en
P2093
Gingras AC
Sonenberg N
von Manteuffel SR
P2860
P304
P407
P577
1997-09-01T00:00:00Z