Retroviral reverse transcriptase: synthesis, structure, and function.
about
Thermostable DNA polymerase from a viral metagenome is a potent RT-PCR enzymeHIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors.Cross- and Co-Packaging of Retroviral RNAs and Their ConsequencesEvidence that the human foamy virus genome is DNAChimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonnucleoside analog inhibitorsHuman immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue cultureMechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTPProteochemometric modeling of the susceptibility of mutated variants of the HIV-1 virus to reverse transcriptase inhibitorsHuman immunodeficiency virus type 1 preintegration complexes containing discontinuous plus strands are competent to integrate in vitroCrystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNAComparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C.Combinations of mutations in the connection domain of human immunodeficiency virus type 1 reverse transcriptase: assessing the impact on nucleoside and nonnucleoside reverse transcriptase inhibitor resistance.Human immunodeficiency virus type 1 nucleocapsid protein can prevent self-priming of minus-strand strong stop DNA by promoting the annealing of short oligonucleotides to hairpin sequences.Impact of Y181C and/or H221Y mutation patterns of HIV-1 reverse transcriptase on phenotypic resistance to available non-nucleoside and nucleoside inhibitors in China.Domain structure of the human immunodeficiency virus reverse transcriptase.Therapeutic strategies underpinning the development of novel techniques for the treatment of HIV infection.Effects of the W153L substitution in HIV reverse transcriptase on viral replication and drug resistance to multiple categories of reverse transcriptase inhibitors.Reduced fitness in cell culture of HIV-1 with nonnucleoside reverse transcriptase inhibitor-resistant mutations correlates with relative levels of reverse transcriptase content and RNase H activity in virions.Profile of Stephen P. Goff. Interview by Greg WilliamsHuman immunodeficiency virus type 1 reverse transcriptase: enhancement of activity by interaction with cellular topoisomerase I.Unique progressive cleavage mechanism of HIV reverse transcriptase RNase HCompensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations.Mechanism of HIV reverse transcriptase inhibition by zinc: formation of a highly stable enzyme-(primer-template) complex with profoundly diminished catalytic activity.Subtype-specific analysis of the K65R substitution in HIV-1 that confers hypersusceptibility to a novel nucleotide-competing reverse transcriptase inhibitor.Alternative divalent cations (Zn²⁺, Co²⁺, and Mn²⁺) are not mutagenic at conditions optimal for HIV-1 reverse transcriptase activity.The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNA(Lys, 3) that correlate with reductions in repEffects on DNA synthesis and translocation caused by mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptaseDetection of an RNase H activity associated with hepadnaviruses.Interference to human immunodeficiency virus type 1 infection in the absence of downmodulation of the principal virus receptor, CD4.A critical role for the TAR element in promoting efficient human immunodeficiency virus type 1 reverse transcriptionvif-negative human immunodeficiency virus type 1 persistently replicates in primary macrophages, producing attenuated progeny virus.In vivo dynamics of equine infectious anemia viruses emerging during febrile episodes: insertions/duplications at the principal neutralizing domainSubunit-specific mutagenesis of the cysteine 280 residue of the reverse transcriptase of human immunodeficiency virus type 1: effects on sensitivity to a specific inhibitor of the RNase H activity.Incorporation of functional human immunodeficiency virus type 1 integrase into virions independent of the Gag-Pol precursor protein.RNase D, a reported new activity associated with HIV-1 reverse transcriptase, displays the same cleavage specificity as Escherichia coli RNase IIIRNase H domain mutations affect the interaction between Moloney murine leukemia virus reverse transcriptase and its primer-templateSubunit-selective mutational analysis and tissue culture evaluations of the interactions of the E138K and M184I mutations in HIV-1 reverse transcriptase.Molecular modeling studies of HIV-1 reverse transcriptase nonnucleoside inhibitors: total energy of complexation as a predictor of drug placement and activity.Cloning, expression, and purification of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase: crystallization of nucleic acid complexes.Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase.
P2860
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P2860
Retroviral reverse transcriptase: synthesis, structure, and function.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Retroviral reverse transcriptase: synthesis, structure, and function.
@ast
Retroviral reverse transcriptase: synthesis, structure, and function.
@en
type
label
Retroviral reverse transcriptase: synthesis, structure, and function.
@ast
Retroviral reverse transcriptase: synthesis, structure, and function.
@en
prefLabel
Retroviral reverse transcriptase: synthesis, structure, and function.
@ast
Retroviral reverse transcriptase: synthesis, structure, and function.
@en
P1476
Retroviral reverse transcriptase: synthesis, structure, and function.
@en
P2093
P304
P577
1990-01-01T00:00:00Z