Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein
about
Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's diseaseA progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") miceCharacterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectorsParkinson's disease: animal models and dopaminergic cell vulnerabilityBehavioral abnormalities and Parkinson's-like histological changes resulting from Id2 inactivation in miceVocalization deficits in mice over-expressing alpha-synuclein, a model of pre-manifest Parkinson's disease.Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulationChronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.Tau reduction does not prevent motor deficits in two mouse models of Parkinson's diseaseIntranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing α-synuclein.Cognitive dysfunction and depression in Parkinson's disease: what can be learned from rodent models?Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.Transglutaminase 2 exacerbates α-synuclein toxicity in mice and yeastImpairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human α-synucleinEnvironmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.A GCase chaperone improves motor function in a mouse model of synucleinopathy.The temporal expression pattern of alpha-synuclein modulates olfactory neurogenesis in transgenic mice.α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter.Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neuronsImpaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons.Animal models of the non-motor features of Parkinson's disease.Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice.Dopamine Transporter Activity Is Modulated by α-Synuclein.Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synucleinMice overexpressing wild-type human alpha-synuclein display alterations in colonic myenteric ganglia and defecation.Research on the premotor symptoms of Parkinson's disease: clinical and etiological implications.In vivo electrophysiology of nigral and thalamic neurons in alpha-synuclein-overexpressing mice highlights differences from toxin-based models of parkinsonism.Cognitive deficits in a mouse model of pre-manifest Parkinson's diseaseAnimal models of Parkinson's disease: a gateway to therapeutics?A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein.How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?Early synaptic dysfunction in Parkinson's disease: Insights from animal models.Alpha-synuclein modulates dopamine neurotransmission.Raft-partitioning of calcium channels regulates their function.Impaired baroreflex function in mice overexpressing alpha-synuclein.Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein.The End Is the Beginning: Parkinson's Disease in the Light of Brain Imaging.Microdialysis in the rat striatum: effects of 24 h dexamethasone retrodialysis on evoked dopamine release and penetration injury.Social Cognition Impairments in Mice Overexpressing Alpha-Synuclein Under the Thy1 Promoter, a Model of Pre-manifest Parkinson's Disease.Exogenous α-Synuclein Monomers Alter Dopamine Metabolism in Murine Brain.
P2860
Q26850502-22B3DC2D-86DC-46C1-AD4C-543C8C762303Q26859072-896FA270-202C-4C5E-9680-A293EBE4ECE8Q27318127-B6B4FD95-91F0-42E9-B91B-4AABD1706294Q28080503-2B22F8FC-20F9-43B9-8FB5-D812782F5DC0Q28591243-1EDCCC1F-F6F2-4F5D-9EFD-5AFF28DA9B74Q30415147-B1159570-9B7C-4B80-B2FF-9248707C5DF8Q30581658-F3338C7D-2098-4B2F-9F36-9D415E6C0B92Q34056025-6500DEFE-F81E-4F90-989C-5E7409D03D60Q34113712-21922DCC-C6C7-48D2-A796-F6CC075333A6Q34292532-5AFB9AAB-3AB3-4F0E-80BF-78EEAD270218Q34307633-5848E928-0469-4D0B-BC05-FCA6C5F2228CQ34325540-855D1E69-5E37-4F0E-AB6D-83540E4F28B4Q34365610-81BB5268-AD14-4C15-864F-0C4DA1AA78B3Q34718257-A38D86B2-6EA1-48E7-9F78-F8BF0A2B3281Q35073958-EF6F1226-B54B-4B1F-8F59-282E64A29EB5Q35340158-5876CF44-5EEC-45C5-B8B2-AED8BCE3B7A1Q35593656-87A77FD9-2D40-47C7-A1CE-AD45A3A5FF69Q35626155-CCD29700-BCE2-468C-8441-5E13007D520BQ35728813-E1680C6C-25CE-4C95-A8A4-9709CA74339BQ35807528-7F02EF47-BF73-4241-BFE5-89362CCC76A0Q36235578-D6C404DA-E76C-4DAA-8F4D-7E244B75587EQ36265332-FBB9FFC4-F36E-4A2B-94E9-86194138C329Q36444116-B77EB124-FE23-4807-B277-7E55164A7F89Q36658992-442CAC73-4D4C-4687-B6DF-FB1BE2EE2060Q37016812-F94F2C59-6664-478D-8B0A-B131E3E53F20Q37374203-A4093D4B-AA2A-4916-88B2-08CF2FA93F44Q37441397-971A9510-255E-4556-B30A-E1DD10EEC760Q37669038-2121E279-6FF5-4E1F-9277-13C5D0222253Q38155480-9CC695EC-7235-43F6-9EF7-52F3E233F1BCQ38741513-1E5C0748-9834-4421-B5EF-2ED82A4A99E7Q38790881-ECE69611-023D-45CF-A55C-1116F44E3835Q38837604-36F360B0-C2AB-4B93-AC35-F29CE4E8E0B3Q38873771-8EFB273C-05AB-47A7-8589-277833B625C7Q41281099-5D057BBC-CFD9-4C0C-A562-E3FFF12B09D5Q41837152-E07E140F-3B8A-4FA0-9186-501E00CE92A3Q41982270-AD9A7DAF-8F6D-46E3-81A8-F8B1233577B0Q42700405-3F3108CC-D058-4825-BC95-19B6445CA473Q43117098-E701951E-96A2-48DE-A709-FEEBD774E63AQ46047010-4B293A42-D27A-41A3-83F6-D7A867F82A89Q46314161-10511966-1533-4869-A161-F336118DBD84
P2860
Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Elevated tonic extracellular d ...... erexpressing human α-synuclein
@ast
Elevated tonic extracellular d ...... erexpressing human α-synuclein
@en
type
label
Elevated tonic extracellular d ...... erexpressing human α-synuclein
@ast
Elevated tonic extracellular d ...... erexpressing human α-synuclein
@en
prefLabel
Elevated tonic extracellular d ...... erexpressing human α-synuclein
@ast
Elevated tonic extracellular d ...... erexpressing human α-synuclein
@en
P2093
P2860
P921
P356
P1476
Elevated tonic extracellular d ...... erexpressing human α-synuclein
@en
P2093
Carlos Cepeda
Franziska Richter
Iddo Magen
Ingrid Cely
Larry C Ackerson
Michael S Levine
Nanping Wu
Nigel T Maidment
Rachel L Kelly
P2860
P304
P356
10.1002/JNR.22611
P577
2011-04-12T00:00:00Z