Cells adapted to high NaCl have many DNA breaks and impaired DNA repair both in cell culture and in vivo.
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MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38deltaHow do kinases contribute to tonicity-dependent regulation of the transcription factor NFAT5?Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaksIntracellular water homeostasis and the mammalian cellular osmotic stress responseNonlinear osmotic properties of the cell nucleus.Gadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress.Increased cancer risk of augmentation cystoplasty: possible role for hyperosmolal microenvironment on DNA damage recognitionMediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP.Pax2 expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance.Cell cycle control and DNA damage response of conditionally immortalized urothelial cells.Replication stress induces micronuclei comprising of aggregated DNA double-strand breaksKu86 preserves chromatin integrity in cells adapted to high NaCl.Global discovery of high-NaCl-induced changes of protein phosphorylationATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis.Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation.Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATRMre11 is expressed in mammalian mitochondria where it binds to mitochondrial DNA.Hyperosmolality triggers oxidative damage in kidney cells.High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNACharacterization and fate of telomerase-expressing epithelia during kidney repairHigh salt and DNA double-strand breaks.DNA double-strand breaks induced by high NaCl occur predominantly in gene desertsMacromolecular crowding regulates assembly of mRNA stress granules after osmotic stress: new role for compatible osmolytesPlacental TonEBP/NFAT5 osmolyte regulation in an ovine model of intrauterine growth restrictionExoMeg1: a new exonuclease from metagenomic library.MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals.RNA-Seq analysis of high NaCl-induced gene expression.DNA damage and osmotic regulation in the kidney.Osmoadaptation of Mammalian cells - an orchestrated network of protective genesNFAT5 in cellular adaptation to hypertonic stress - regulations and functional significanceAnalysis of DNA breaks, DNA damage response, and apoptosis produced by high NaCl.Knockout of Ku86 accelerates cellular senescence induced by high NaCl.Solvent-free Fabrication of Tissue Engineering Scaffolds with Immiscible Polymer Blends.Ambient tonicity and intestinal cytochrome CYP3A.Primary cilia regulate the osmotic stress response of renal epithelial cells through TRPM3.Repeated H2 O2 exposure drives cell cycle progression in an in vitro model of ulcerative colitis.Gap junctions favor normal rat kidney epithelial cell adaptation to chronic hypertonicity.Src kinase pathway is involved in NFAT5-mediated S100A4 induction by hyperosmotic stress in colon cancer cells.Mre11-Rad50-Nbs1 complex is activated by hypertonicity.
P2860
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P2860
Cells adapted to high NaCl have many DNA breaks and impaired DNA repair both in cell culture and in vivo.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Cells adapted to high NaCl hav ...... h in cell culture and in vivo.
@ast
Cells adapted to high NaCl hav ...... h in cell culture and in vivo.
@en
type
label
Cells adapted to high NaCl hav ...... h in cell culture and in vivo.
@ast
Cells adapted to high NaCl hav ...... h in cell culture and in vivo.
@en
prefLabel
Cells adapted to high NaCl hav ...... h in cell culture and in vivo.
@ast
Cells adapted to high NaCl hav ...... h in cell culture and in vivo.
@en
P2860
P356
P1476
Cells adapted to high NaCl hav ...... h in cell culture and in vivo.
@en
P2093
Maurice B Burg
P2860
P304
P356
10.1073/PNAS.0308463100
P407
P577
2004-02-01T00:00:00Z