Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition.
about
mTOR is a key modulator of ageing and age-related diseaseChemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processesLithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cellsPrinciples of alternative gerontologyReprogramming of energy metabolism as a driver of agingAlpha-Ketoglutarate: Physiological Functions and ApplicationsA novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosisCaloric restriction: is mammalian life extension linked to p53?Rapalogs in cancer prevention: anti-aging or anticancer?The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repairIron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesEvolution of sexually dimorphic longevity in humansBig mice die young but large animals live longerWhy men age faster but reproduce longer than women: mTOR and evolutionary perspectivesDiscovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processesHyper-mitogenic drive coexists with mitotic incompetence in senescent cells.Oxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation.Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?Dynamic regulation of genetic pathways and targets during aging in Caenorhabditis elegans.Growth and aging: a common molecular mechanism.Inhibition of S6K by resveratrol: in search of the purposeTarget of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration.From rapalogs to anti-aging formula.The key role of growth hormone-insulin-IGF-1 signaling in aging and cancerWhy human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis.Late-life rapamycin treatment reverses age-related heart dysfunction.Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry".Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level.Rapamycin slows aging in miceMechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acidIn silico discovery of novel transcription factors regulated by mTOR-pathway activities.TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.Selective anti-cancer agents as anti-aging drugsLongevity, aging and rapamycin.Metformin for aging and cancer prevention.Why the disposable soma theory cannot explain why women live longer and why we age.Metformin and sex: Why suppression of aging may be harmful to young male mice.Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv miceRole of TOR signaling in aging and related biological processes in Drosophila melanogasterLoss of Nfkb1 leads to early onset aging
P2860
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P2860
Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition.
@ast
Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition.
@en
type
label
Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition.
@ast
Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition.
@en
prefLabel
Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition.
@ast
Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition.
@en
P356
P1433
P1476
Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition.
@en
P304
P356
10.4161/CC.5.18.3288
P577
2006-09-15T00:00:00Z