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mTOR is a key modulator of ageing and age-related diseaseImpact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effectsFinding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging MoleculesGeroscience approaches to increase healthspan and slow agingInhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and BeyondOlive Oil and the Hallmarks of AgingBiochemical Genetic Pathways that Modulate Aging in Multiple SpeciesFK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?Rapalogs in cancer prevention: anti-aging or anticancer?Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degenerationThe measurement of protein synthesis for assessing proteostasis in studies of slowed agingTherapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New TricksCellular and molecular biology of aging endothelial cellsLongevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intakeQuality control systems in cardiac agingEssential role for autophagy in life span extensionThe hallmarks of agingIntermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J MiceThe Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingRapalogs and mTOR inhibitors as anti-aging therapeuticsIncreased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expressionRapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restrictionMice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptomeLifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycinMitochondrial Metabolism in Aging HeartStaying young at heart: autophagy and adaptation to cardiac aging10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin SignalingBig mice die young but large animals live longerEnergy intake and exercise as determinants of brain health and vulnerability to injury and diseaseCurrent aging research in China.Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells.Rapamycin extends murine lifespan but has limited effects on aging.Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease.Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strainThe effects of dietary restriction on oxidative stress in rodents.Preserving youth: does rapamycin deliver?Recent progress in metabolic signaling pathways regulating aging and life spanMethionine restriction activates the retrograde response and confers both stress tolerance and lifespan extension to yeast, mouse and human cellsLow abundance of the matrix arm of complex I in mitochondria predicts longevity in mice.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Rapamycin slows aging in mice
@ast
Rapamycin slows aging in mice
@en
Rapamycin slows aging in mice
@nl
type
label
Rapamycin slows aging in mice
@ast
Rapamycin slows aging in mice
@en
Rapamycin slows aging in mice
@nl
prefLabel
Rapamycin slows aging in mice
@ast
Rapamycin slows aging in mice
@en
Rapamycin slows aging in mice
@nl
P2093
P2860
P1433
P1476
Rapamycin slows aging in mice
@en
P2093
Chi-Chao Chan
David E Harrison
James F Hejtmancik
John E Wilkinson
Lauren K Wood
Lisa Burmeister
Nancy Nadon
Randy Strong
Richard A Miller
Sabrina Friedline
P2860
P304
P356
10.1111/J.1474-9726.2012.00832.X
P577
2012-06-04T00:00:00Z