The dark energy of proteins comes to light: conformational entropy and its role in protein function revealed by NMR relaxation.
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Correlation as a determinant of configurational entropy in supramolecular and protein systemsThe ensemble nature of allosteryPrinciples of allosteric interactions in cell signalingExploring the role of conformational heterogeneity in cis-autoproteolytic activation of ThnT.On the relationship between NMR-derived amide order parameters and protein backbone entropy changesLoss of conformational entropy in protein folding calculated using realistic ensembles and its implications for NMR-based calculationsThe RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRASShortening a loop can increase protein native state entropy.Integrating atomistic molecular dynamics simulations, experiments, and network analysis to study protein dynamics: strength in unity.SARA: a software environment for the analysis of relaxation data acquired with accordion spectroscopy.Banding of NMR-derived methyl order parameters: implications for protein dynamics.Insight into the allosteric mechanism of Scapharca dimeric hemoglobinDominant Alcohol-Protein Interaction via Hydration-Enabled Enthalpy-Driven Binding MechanismThe role of dimer asymmetry and protomer dynamics in enzyme catalysis.Contrasting roles of dynamics in protein allostery: NMR and structural studies of CheY and the third PDZ domain from PSD-95.Disordered allostery: lessons from glucocorticoid receptor.Computational approaches to mapping allosteric pathways.Measuring similarity between dynamic ensembles of biomolecules(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus.The binding mechanisms of intrinsically disordered proteins.Discovery of multiple hidden allosteric sites by combining Markov state models and experimentsDual allosteric activation mechanisms in monomeric human glucokinase.Entropy in molecular recognition by proteins.The S2 Cu(i) site in CupA from Streptococcus pneumoniae is required for cellular copper resistance.Disorder transitions and conformational diversity cooperatively modulate biological function in proteins.Connecting protein conformational dynamics with catalytic function as illustrated in dihydrofolate reductase.Protein Allostery and Conformational Dynamics.Role of conformational entropy in the activity and regulation of the catalytic subunit of protein kinase A.Microscopic insights into the NMR relaxation-based protein conformational entropy meterEntropic origin of cobalt-carbon bond cleavage catalysis in adenosylcobalamin-dependent ethanolamine ammonia-lyase.Thermodynamic and structural basis for relaxation of specificity in protein-DNA recognitionInformation flow and protein dynamics: the interplay between nuclear magnetic resonance spectroscopy and molecular dynamics simulations.A Unique and Simple Approach to Improve Sensitivity in 15N-NMR Relaxation Measurements for NH₃⁺ Groups: Application to a Protein-DNA Complex.Protein dynamics and function from solution state NMR spectroscopy.Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.A look at ligand binding thermodynamics in drug discovery.The unusual internal motion of the villin headpiece subdomain.Site-Specific Internal Motions in GB1 Protein Microcrystals Revealed by 3D ²H-¹³C-¹³C Solid-State NMR SpectroscopyRNA Thermodynamic Structural Entropy.Redesigning protein cavities as a strategy for increasing affinity in protein-protein interaction: interferon- γ receptor 1 as a model.
P2860
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P2860
The dark energy of proteins comes to light: conformational entropy and its role in protein function revealed by NMR relaxation.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
The dark energy of proteins co ...... on revealed by NMR relaxation.
@ast
The dark energy of proteins co ...... on revealed by NMR relaxation.
@en
type
label
The dark energy of proteins co ...... on revealed by NMR relaxation.
@ast
The dark energy of proteins co ...... on revealed by NMR relaxation.
@en
prefLabel
The dark energy of proteins co ...... on revealed by NMR relaxation.
@ast
The dark energy of proteins co ...... on revealed by NMR relaxation.
@en
P2860
P1476
The dark energy of proteins co ...... on revealed by NMR relaxation.
@en
P2093
A Joshua Wand
P2860
P356
10.1016/J.SBI.2012.11.005
P577
2012-12-13T00:00:00Z