Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
about
RhoC regulates the proliferation of gastric cancer cells through interaction with IQGAP1Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cellsRhoA: a therapeutic target for chronic myeloid leukemiaCo-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasionDynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalkApproaches of targeting Rho GTPases in cancer drug discoveryMutationally activated Rho GTPases in cancerRho GTPases and their roles in cancer metabolismRegulation of ROCK activity in cancermTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling AxisReal-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho.Cdc42 in oncogenic transformation, invasion, and tumorigenesisP190A RhoGAP is required for mammary gland developmentRac1 controls the subcellular localization of the Rho guanine nucleotide exchange factor Net1A to regulate focal adhesion formation and cell spreadingBi-directional signaling: extracellular matrix and integrin regulation of breast tumor progressionProteomic characterization of novel alternative splice variant proteins in human epidermal growth factor receptor 2/neu-induced breast cancersInhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer.Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis.ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasionPreclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines.Genes and proteins differentially expressed during in vitro malignant transformation of bovine pancreatic duct cells.Epigenetic regulation of RhoB loss of expression in lung cancerDistinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture.Alteration in protein expression in estrogen receptor alpha-negative human breast cancer tissues indicates a malignant and metastatic phenotype.Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer.CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis.Co-expression of delta-catenin and RhoA is significantly associated with a malignant lung cancer phenotypep53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cellsAtorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cellsPDZ and LIM domain protein 1(PDLIM1)/CLP36 promotes breast cancer cell migration, invasion and metastasis through interaction with α-actinin.Essential role of Cdc42 in Ras-induced transformation revealed by gene targetingModeling truncated AR expression in a natural androgen responsive environment and identification of RHOB as a direct transcriptional target.P190B RhoGAP overexpression in the developing mammary epithelium induces TGFβ-dependent fibroblast activationRole of activated Rac1/Cdc42 in mediating endothelial cell proliferation and tumor angiogenesis in breast cancer.Targeting mitochondrial glutaminase activity inhibits oncogenic transformation.P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis.Regulation of Rho-GEF Rgf3 by the arrestin Art1 in fission yeast cytokinesis.Roles and regulation of stat family transcription factors in human breast cancer.Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?
P2860
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P2860
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Rho GTPases in human breast tu ...... ation with clinical parameters
@ast
Rho GTPases in human breast tu ...... ation with clinical parameters
@en
type
label
Rho GTPases in human breast tu ...... ation with clinical parameters
@ast
Rho GTPases in human breast tu ...... ation with clinical parameters
@en
prefLabel
Rho GTPases in human breast tu ...... ation with clinical parameters
@ast
Rho GTPases in human breast tu ...... ation with clinical parameters
@en
P2093
P2860
P356
P1476
Rho GTPases in human breast tu ...... ation with clinical parameters
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.BJC.6600510
P407
P577
2002-09-01T00:00:00Z