Molecular switch in signal transduction: reaction paths of the conformational changes in ras p21.
about
Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesisCHARMM: the biomolecular simulation programPrinciples and Overview of Sampling Methods for Modeling Macromolecular Structure and DynamicsThe distinct conformational dynamics of K-Ras and H-Ras A59GRas conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamicsThe structural basis for the transition from Ras-GTP to Ras-GDPDiscovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activationp19ras brings a new twist to the regulation of p73 by Mdm2The catecholaminergic polymorphic ventricular tachycardia mutation R33Q disrupts the N-terminal structural motif that regulates reversible calsequestrin polymerizationQuantifying information transfer by protein domains: analysis of the Fyn SH2 domain structureProtein complex formation by acetylcholinesterase and the neurotoxin fasciculin-2 appears to involve an induced-fit mechanism.Segmented transition pathway of the signaling protein nitrogen regulatory protein CSelection of phage-displayed fab antibodies on the active conformation of ras yields a high affinity conformation-specific antibody preventing the binding of c-Raf kinase to Ras.Optimization and evaluation of a coarse-grained model of protein motion using x-ray crystal data.Allosteric transitions of supramolecular systems explored by network models: application to chaperonin GroEL.Large-scale evaluation of dynamically important residues in proteins predicted by the perturbation analysis of a coarse-grained elastic modelA computational analysis of ATP binding of SV40 large tumor antigen helicase motor.The conformational transition pathway of ATP binding cassette transporter MsbA revealed by atomistic simulations.Mechanical force generation by G proteinsConformational pathways in the gating of Escherichia coli mechanosensitive channel.Investigation of pathways for the low-pH conformational transition in influenza hemagglutinin.Molecular dynamics simulation of protein folding by essential dynamics sampling: folding landscape of horse heart cytochrome cDesigning human m1 muscarinic receptor-targeted hydrophobic eigenmode matched peptides as functional modulatorsMechanism of the exchange reaction in HRAS from multiscale modelingCellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38Functional dynamics of PDZ binding domains: a normal-mode analysisConformational transitions in protein-protein association: binding of fasciculin-2 to acetylcholinesterase.Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation.Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB.Dynamics of Recognition between tRNA and elongation factor TuMapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary Algorithm.The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP.Target molecular simulations of RecA family protein filamentsThe allosteric mechanism of the chaperonin GroEL: a dynamic analysis.Specific Conformational States of Ras GTPase upon Effector BindingThe Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.Allosteric transition pathways in the lactose repressor protein core domains: asymmetric motions in a homodimer.End-point targeted molecular dynamics: large-scale conformational changes in potassium channels.Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins.Activation mechanism of a signaling protein at atomic resolution from advanced computations
P2860
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P2860
Molecular switch in signal transduction: reaction paths of the conformational changes in ras p21.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Molecular switch in signal tra ...... ormational changes in ras p21.
@ast
Molecular switch in signal tra ...... ormational changes in ras p21.
@en
type
label
Molecular switch in signal tra ...... ormational changes in ras p21.
@ast
Molecular switch in signal tra ...... ormational changes in ras p21.
@en
prefLabel
Molecular switch in signal tra ...... ormational changes in ras p21.
@ast
Molecular switch in signal tra ...... ormational changes in ras p21.
@en
P2860
P356
P1476
Molecular switch in signal tra ...... ormational changes in ras p21.
@en
P2860
P304
11905-11910
P356
10.1073/PNAS.94.22.11905
P407
P577
1997-10-01T00:00:00Z