Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. - Wikidata - wikimedia - TriplyDB

Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys.

Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys.

http://www.wikidata.org/entity/Q36627986

about

Emerging concepts in the immunopathogenesis of AIDS Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts Nonpathogenic simian immunodeficiency virus infections Natural SIV hosts: showing AIDS the door A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo Inadequate clearance of translocated bacterial products in HIV-infected humanized mice The simian immunodeficiency virus targets central cell cycle functions through transcriptional repression in vivo Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection Re-evaluation of PD-1 expression by T cells as a marker for immune exhaustion during SIV infection Kinetics of myeloid dendritic cell trafficking and activation: impact on progressive, nonprogressive and controlled SIV infections Intact type I Interferon production and IRF7 function in sooty mangabeys SIVagm infection in wild African green monkeys from South Africa: epidemiology, natural history, and evolutionary considerations Immune restoration after antiretroviral therapy: the pitfalls of hasty or incomplete repairs.Immune activation and paediatric HIV-1 disease outcome Antibiotic and Antiinflammatory Therapy Transiently Reduces Inflammation and Hypercoagulation in Acutely SIV-Infected Pigtailed Macaques Deep transcriptional sequencing of mucosal challenge compartment from rhesus macaques acutely infected with simian immunodeficiency virus implicates loss of cell adhesion preceding immune activation Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.Going wild: lessons from naturally occurring T-lymphotropic lentiviruses Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies Paucity of CD4+ natural killer T (NKT) lymphocytes in sooty mangabeys is associated with lack of NKT cell depletion after SIV infection.Cycling memory CD4+ T cells in HIV disease have a diverse T cell receptor repertoire and a phenotype consistent with bystander activation.Rabies virus-based vaccines elicit neutralizing antibodies, poly-functional CD8+ T cell, and protect rhesus macaques from AIDS-like disease after SIV(mac251) challenge.Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections.Similar impact of CD8+ T cell responses on early virus dynamics during SIV infections of rhesus macaques and sooty mangabeys.Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts.The loss of CCR6+ and CD161+ CD4+ T-cell homeostasis contributes to disease progression in SIV-infected rhesus macaques.Unraveling the relationship between microbial translocation and systemic immune activation in HIV infection A five-year longitudinal analysis of sooty mangabeys naturally infected with simian immunodeficiency virus reveals a slow but progressive decline in CD4+ T-cell count whose magnitude is not predicted by viral load or immune activation Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy.Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques.Immune dysregulation in human immunodeficiency virus infection: know it, fix it, prevent it?Nonprogressive and progressive primate immunodeficiency lentivirus infections.Innate immune recognition and activation during HIV infection.Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells.Dysregulation of multiple inflammatory molecules in lymph node and ileum of macaques during RT-SHIV infection with or without antiretroviral therapy Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques.Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques.

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P2860

Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys.

http://www.wikidata.org/entity/Q36627986

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2007 nî lūn-bûn

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2007年论文

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Severe depletion of mucosal CD ...... irus-infected sooty mangabeys.

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Severe depletion of mucosal CD ...... irus-infected sooty mangabeys.

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Severe depletion of mucosal CD ...... irus-infected sooty mangabeys.

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Severe depletion of mucosal CD ...... irus-infected sooty mangabeys.

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Severe depletion of mucosal CD ...... irus-infected sooty mangabeys.

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Journal of Immunology

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Severe depletion of mucosal CD ...... irus-infected sooty mangabeys.

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Ali Danesh

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Daniel C Douek

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David Kelvin

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Donald L Sodora

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Elizabeth A Strobert

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Guido Silvestri

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Ivona V Pandrea

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Jason M Brenchley

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Jeffrey M Milush

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Jessica C Engram

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P2860

CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract

Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates

AIDS as a zoonosis: scientific and public health implications

Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection.

Divergent host responses during primary simian immunodeficiency virus SIVsm infection of natural sooty mangabey and nonnatural rhesus macaque hosts

Simian immunodeficiency virus replicates to high levels in sooty mangabeys without inducing disease.

The dynamics of CD4+ T-cell depletion in HIV disease.

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3026-3034

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10.4049/JIMMUNOL.179.5.3026

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6129488

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17709517

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Simian immunodeficiency virus

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