Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01
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Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle DisordersThe bestrophin- and TMEM16A-associated Ca(2+)- activated Cl(–) channels in vascular smooth musclesA Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipidCellular functions of TMEM16/anoctaminInhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cellsAni9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2Anoctamin-1 Cl(-) channels in nociception: activation by an N-aroylaminothiazole and capsaicin and inhibition by T16A[inh]-A01Hypoxia augments the calcium-activated chloride current carried by anoctamin-1 in cardiac vascular endothelial cells of neonatal mice.Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptorCharacterization of Cardiac Anoctamin1 Ca²⁺-Activated Chloride Channels and Functional Role in Ischemia-Induced ArrhythmiasANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC)Molecular and functional significance of Ca(2+)-activated Cl(-) channels in pulmonary arterial smooth muscle.Effects of new-generation inhibitors of the calcium-activated chloride channel anoctamin 1 on slow waves in the gastrointestinal tract.Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1.New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit?Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension.Mechanosensitive Cl- secretion in biliary epithelium mediated through TMEM16A.Regulation of cerebral artery smooth muscle membrane potential by Ca²⁺-activated cation channels.Effective contractile response to voltage-gated Na+ channels revealed by a channel activator.TRPC1 regulates calcium-activated chloride channels in salivary gland cells.Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries.Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours.Cl⁻ channels in smooth muscle cells.Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin.Regulation of vascular tone and arterial blood pressure: role of chloride transport in vascular smooth muscle.Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal.Influence of intracellular Ca2+ and alternative splicing on the pharmacological profile of ANO1 channels.Increased TMEM16A Involved in Alveolar Fluid Clearance After Lipopolysaccharide Stimulation.Negative News: Cl- and HCO3- in the Vascular Wall.Niflumic acid affects store-operated Ca(2+)-permeable (SOC) and Ca (2+)-dependent K (+) and Cl (-) ion channels and induces apoptosis in K562 cells.Anoctamin 1 (Ano1) is required for glucose-induced membrane potential oscillations and insulin secretion by murine β-cells.ANO1 in intramuscular interstitial cells of Cajal plays a key role in the generation of slow waves and tone in the internal anal sphincter.Pharmacological characterization of TMEM16A currents9-Phenanthrol inhibits recombinant and arterial myocyte TMEM16A channels.Mechanisms underlying spontaneous constrictions of postcapillary venules in the rat stomach.Inhibitory role of phosphatidylinositol 4,5-bisphosphate on TMEM16A-encoded calcium-activated chloride channels in rat pulmonary artery.Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A).Developmental expression of the calcium-activated chloride channels TMEM16A and TMEM16B in the mouse olfactory epithelium.
P2860
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P2860
Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01
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2013 nî lūn-bûn
@nan
2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
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2013年论文
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name
Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01
@ast
Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01
@en
type
label
Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01
@ast
Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01
@en
prefLabel
Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01
@ast
Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01
@en
P2093
P2860
P50
P1476
Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01
@en
P2093
A S Verkman
Alison J Davis
Georgios Vasilikostas
Normand Leblanc
Preet S Chadha
P2860
P304
P356
10.1111/J.1476-5381.2012.02199.X
P407
P577
2013-02-01T00:00:00Z