Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex
about
Eukaryote-specific extensions in ribosomal proteins of the small subunit: Structure and functionWhy is start codon selection so precise in eukaryotes?Quantitative studies of mRNA recruitment to the eukaryotic ribosomeRps5-Rps16 communication is essential for efficient translation initiation in yeast S. cerevisiae.Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complexStructural changes enable start codon recognition by the eukaryotic translation initiation complex.Human eukaryotic initiation factor 2 (eIF2)-GTP-Met-tRNAi ternary complex and eIF3 stabilize the 43 S preinitiation complex.eIF5 and eIF5B together stimulate 48S initiation complex formation during ribosomal scanning.Conformational changes in the P site and mRNA entry channel evoked by AUG recognition in yeast translation preinitiation complexesQuantitative analysis of mammalian translation initiation sites by FACS-seqMechanism of cytoplasmic mRNA translation.The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo.Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex.Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes.Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.β-Hairpin loop of eukaryotic initiation factor 1 (eIF1) mediates 40 S ribosome binding to regulate initiator tRNA(Met) recruitment and accuracy of AUG selection in vivo.eIF1A/eIF5B interaction network and its functions in translation initiation complex assembly and remodeling.Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy.The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling.Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon.Active yeast ribosome preparation using monolithic anion exchange chromatography.Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysisInitiation codon selection is accomplished by a scanning mechanism without crucial initiation factors in Sindbis virus subgenomic mRNA.The molecular choreography of protein synthesis: translational control, regulation, and pathways.ABCE1: A special factor that orchestrates translation at the crossroad between recycling and initiation.Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide.eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast.The Regulation of Translation in Alphavirus-Infected Cells.Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors.Translational autoregulation of BZW1 and BZW2 expression by modulating the stringency of start codon selection.Overexpression of eukaryotic initiation factor 5 rescues the translational defect of tpk1w in a manner that necessitates a novel phosphorylation site.Human eIF5 and eIF1A Compete for Binding to eIF5B
P2860
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P2860
Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
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2013年论文
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2013年论文
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name
Coordinated movements of eukar ...... ibosomal preinitiation complex
@ast
Coordinated movements of eukar ...... ibosomal preinitiation complex
@en
type
label
Coordinated movements of eukar ...... ibosomal preinitiation complex
@ast
Coordinated movements of eukar ...... ibosomal preinitiation complex
@en
prefLabel
Coordinated movements of eukar ...... ibosomal preinitiation complex
@ast
Coordinated movements of eukar ...... ibosomal preinitiation complex
@en
P2093
P2860
P356
P1476
Coordinated movements of eukar ...... ibosomal preinitiation complex
@en
P2093
Alan G Hinnebusch
Antonio M Muñoz
Jagpreet S Nanda
P2860
P304
P356
10.1074/JBC.M112.440693
P407
P577
2013-01-04T00:00:00Z