ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo.
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ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkinFunctional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosisLimited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis PigmentosaDivergent effects of PERK and IRE1 signaling on cell viabilityBOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated DegradationMolecular pathway of near-infrared laser phototoxicity involves ATF-4 orchestrated ER stressFine tuning of the UPR by the ubiquitin ligases Siah1/2.Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.Brief report: stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes.Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+)Midnolin is a novel regulator of parkin expression and is associated with Parkinson's DiseaseEndoplasmic reticulum stress and the unfolded protein responses in retinal degeneration.Dysregulation of system xc(-) expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 miceHydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibitionHsp27 binding to the 3'UTR of bim mRNA prevents neuronal death during oxidative stress-induced injury: a novel cytoprotective mechanism.Spatial, temporal, and quantitative manipulation of intracellular hydrogen peroxide in cultured cells.A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis.Deletion of the pro-apoptotic endoplasmic reticulum stress response effector CHOP does not result in improved locomotor function after severe contusive spinal cord injuryIntegrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism.Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models.ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosisHypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?Attenuating the endoplasmic reticulum stress response improves functional recovery after spinal cord injury.Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes.MKP-1 antagonizes C/EBPβ activity and lowers the apoptotic threshold after ischemic injuryEnhanced Expression of Trib3 during the Development of Myelin Breakdown in dmy Myelin Mutant Rats.Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation.ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.Placental endoplasmic reticulum stress negatively regulates transcription of placental growth factor via ATF4 and ATF6β: implications for the pathophysiology of human pregnancy complicationsAutophagy protects the retina from light-induced degenerationTumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress.ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation.Restoring endoplasmic reticulum homeostasis improves functional recovery after spinal cord injury.Modulation of angiogenesis by genetic manipulation of ATF4 in mouse model of oxygen-induced retinopathy [corrected].Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy.The transcription factor ATF5: role in neurodevelopment and neural tumors.Improved antibody production in Chinese hamster ovary cells by ATF4 overexpressionATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression.
P2860
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P2860
ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
ATF4 is an oxidative stress-in ...... neurons in vitro and in vivo.
@ast
ATF4 is an oxidative stress-in ...... neurons in vitro and in vivo.
@en
type
label
ATF4 is an oxidative stress-in ...... neurons in vitro and in vivo.
@ast
ATF4 is an oxidative stress-in ...... neurons in vitro and in vivo.
@en
prefLabel
ATF4 is an oxidative stress-in ...... neurons in vitro and in vivo.
@ast
ATF4 is an oxidative stress-in ...... neurons in vitro and in vivo.
@en
P2093
P2860
P356
P1476
ATF4 is an oxidative stress-in ...... neurons in vitro and in vivo.
@en
P2093
Chiao-Wang Sun
Daniel H Geschwind
Giovanni Coppola
John T Pinto
Juan C Chavez
Philipp S Lange
Rajiv R Ratan
Tim M Townes
P2860
P304
P356
10.1084/JEM.20071460
P407
P577
2008-05-05T00:00:00Z