Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain.
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Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brainDISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injuryThe role of lipid peroxidation in neurological disordersOxidized cholesterol as the driving force behind the development of Alzheimer's diseaseEnhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivoEffects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 miceEfficacy and ototoxicity of different cyclodextrins in Niemann-Pick C diseaseMarkers of cholesterol transport are associated with amyloid deposition in the brain.Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease.Deletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehaviorCholesterol-modifying strategies for Alzheimer's disease.Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brainMidlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later.Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain CancersMarked variability in hepatic expression of cytochromes CYP7A1 and CYP27A1 as compared to cerebral CYP46A1. Lessons from a dietary study with omega 3 fatty acids in hamsters.Modulation of cholesterol in midlife affords cognitive advantage during ageing - a role for altered redox balanceSTARTing to understand MLN64 function in cholesterol transport.Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study.Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degenerationRecombinant adenovirus-mediated overexpression of 3β-hydroxysteroid-Δ24 reductase.Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain.Linking cardiometabolic disorders to sporadic Alzheimer's disease: a perspective on potential mechanisms and mediators.AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease.The ins and outs of cholesterol in the vertebrate retina.Malformation syndromes caused by disorders of cholesterol synthesis.Steady-state levels of retinal 24S-hydroxycholesterol are maintained by glial cells intervention after elevation of intraocular pressure in the rat.Plasma levels of HDL and carotenoids are lower in dementia patients with vascular comorbidities.Cholesterol in brain disease: sometimes determinant and frequently implicated.Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?Cholesterol metabolism and homeostasis in the brainGene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia.Lipids under stress--a lipidomic approach for the study of mood disorders.Cholesterol metabolites exported from human brain.Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease.Induction of mitochondrial changes associated with oxidative stress on very long chain fatty acids (C22:0, C24:0, or C26:0)-treated human neuronal cells (SK-NB-E).Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer's disease.Ligands of Therapeutic Utility for the Liver X Receptors.
P2860
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P2860
Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Crossing the barrier: oxystero ...... bolic modulators in the brain.
@ast
Crossing the barrier: oxystero ...... bolic modulators in the brain.
@en
type
label
Crossing the barrier: oxystero ...... bolic modulators in the brain.
@ast
Crossing the barrier: oxystero ...... bolic modulators in the brain.
@en
prefLabel
Crossing the barrier: oxystero ...... bolic modulators in the brain.
@ast
Crossing the barrier: oxystero ...... bolic modulators in the brain.
@en
P2860
P1476
Crossing the barrier: oxystero ...... abolic modulators in the brain
@en
P2860
P304
P356
10.1111/J.1365-2796.2006.01725.X
P407
P577
2006-12-01T00:00:00Z