Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization

Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization

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http://www.wikidata.org/entity/Q36661746

Q36661746

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Subfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence Sustained Pax6 Expression Generates Primate-like Basal Radial Glia in Developing Mouse Neocortex Differential regulation of telencephalic pallial-subpallial boundary patterning by Pax6 and Gsh2 Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals Gdf11 facilitates temporal progression of neurogenesis in the developing spinal cord Er81 is a downstream target of Pax6 in cortical progenitors.Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance A Boolean model of the gene regulatory network underlying Mammalian cortical area development DNaseI hypersensitivity and ultraconservation reveal novel, interdependent long-range enhancers at the complex Pax6 cis-regulatory region.Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice.The cortical hem regulates the size and patterning of neocortex The generation of superficial cortical layers is regulated by levels of the transcription factor Pax6 Pax6 is essential for the maintenance and multi-lineage differentiation of neural stem cells, and for neuronal incorporation into the adult olfactory bulb.Gradients in the brain: the control of the development of form and function in the cerebral cortex.The transcription factor Foxg1 regulates telencephalic progenitor proliferation cell autonomously, in part by controlling Pax6 expression levels.Identification of genomic regions regulating Pax6 expression in embryonic forebrain using YAC reporter transgenic mouse lines.Overexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: changes in immune function, vascularization, and differentiation.Lessons from mouse chimaera experiments with a reiterated transgene marker: revised marker criteria and a review of chimaera markers Regional Volume Decreases in the Brain of Pax6 Heterozygous Mutant Rats: MRI Deformation-Based Morphometry Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders Lateral cortical Cdca7 expression levels are regulated by Pax6 and influence the production of intermediate progenitors Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development.Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus A microRNA-328 binding site in PAX6 is associated with centrotemporal spikes of rolandic epilepsy.Activation of Pax3 target genes is necessary but not sufficient for neurogenesis in the ophthalmic trigeminal placode.Progressive loss of PAX6, TBR2, NEUROD and TBR1 mRNA gradients correlates with translocation of EMX2 to the cortical plate during human cortical development.Genetic regulation of arealization of the neocortex Altered molecular regionalization and normal thalamocortical connections in cortex-specific Pax6 knock-out mice.Effects of elevated Pax6 expression and genetic background on mouse eye development.The role of Pax6 in forebrain development.Neocortical arealization: evolution, mechanisms, and open questions.Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor.The long non-coding RNA Paupar regulates the expression of both local and distal genes.Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region.The Pax6b homeodomain is dispensable for pancreatic endocrine cell differentiation in zebrafish.Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6.

P2860

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P2860

Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization

Item

http://www.wikidata.org/entity/Q36661746

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Controlled overexpression of P ...... ffect on cortical arealization

@ast

Controlled overexpression of P ...... ffect on cortical arealization

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type

Item

label

Controlled overexpression of P ...... ffect on cortical arealization

@ast

Controlled overexpression of P ...... ffect on cortical arealization

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prefLabel

Controlled overexpression of P ...... ffect on cortical arealization

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Controlled overexpression of P ...... ffect on cortical arealization

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P1476

Controlled overexpression of P ...... ffect on cortical arealization

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P2093

Ben Martynoga

http://www.w3.org/2001/XMLSchema#string

Catherine B Carr

http://www.w3.org/2001/XMLSchema#string

David A Tyas

http://www.w3.org/2001/XMLSchema#string

Jeni Pinson

http://www.w3.org/2001/XMLSchema#string

John D West

http://www.w3.org/2001/XMLSchema#string

Michael Molinek

http://www.w3.org/2001/XMLSchema#string

Petrina A Georgala

http://www.w3.org/2001/XMLSchema#string

Simon Chanas

http://www.w3.org/2001/XMLSchema#string

T Ian Simpson

http://www.w3.org/2001/XMLSchema#string

P2860

Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene

Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways

Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development

Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis

The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse

Emx1, emx2 and pax6 in specification, regionalization and arealization of the cerebral cortex

Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain

Ventralized dorsal telencephalic progenitors in Pax6 mutant mice generate GABA interneurons of a lateral ganglionic eminence fate.

Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex

Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb

P304

545-555

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scholarly article

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10.1242/DEV.02764

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English

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134

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Veronica van Heyningen

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2007-01-03T00:00:00Z

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6599163

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17202185

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overexpression

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2386558

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Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization

about

P2860

P2860

Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization

description

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P1433

P1476

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P2860

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P356

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