STAT3 as a central mediator of neoplastic cellular transformation.
about
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cellsAcetylation directs survivin nuclear localization to repress STAT3 oncogenic activitySTAT1 activation regulates proliferation and differentiation of renal progenitorsAn epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformationCommon stemness regulators of embryonic and cancer stem cellsThe Complex Role of STAT3 in Viral InfectionsSTAT3 inhibitors for cancer therapy: Have all roads been explored?Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicityOverrepresentation of transcription factor families in the genesets underlying breast cancer subtypesCross-species genome wide expression analysis during pluripotent cell determination in mouse and rat preimplantation embryosOptimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitorsHCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell linesUltrasound Targeted Microbubble Destruction-Mediated Delivery of a Transcription Factor Decoy Inhibits STAT3 Signaling and Tumor GrowthHigh-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines.Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cellsRole of STAT3 in cancer metastasis and translational advances.A model for the epigenetic switch linking inflammation to cell transformation: deterministic and stochastic approachesNifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6.MicroRNA-1299 is a negative regulator of STAT3 in colon cancerIdentification of a Stat3-dependent transcription regulatory network involved in metastatic progression.Cell cycle, oncogenic and tumor suppressor pathways regulate numerous long and macro non-protein-coding RNAs.STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b.A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-κB.Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristicsAberrant sonic hedgehog signaling pathway and STAT3 activation in papillary thyroid cancer.Proteomic screening identifies a YAP-driven signaling network linked to tumor cell proliferation in human schwannomasSTAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer.Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathwayDown-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers.AZD1480 delays tumor growth in a melanoma model while enhancing the suppressive activity of myeloid-derived suppressor cells.XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells.Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release.STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypesStat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinomaDevelopment of a novel azaspirane that targets the Janus kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivoInhibition of STAT3-interacting protein 1 (STATIP1) promotes STAT3 transcriptional up-regulation and imatinib mesylate resistance in the chronic myeloid leukemia.The role of chalcones in suppression of NF-κB-mediated inflammation and cancer.STAT3 signaling: anticancer strategies and challenges.Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells.
P2860
Q24293124-04C43147-0203-47CA-8BB4-D3D9F2EFCEE4Q24299156-FF058995-A16C-414F-A0D2-26F1F0EAB9A4Q24338667-4883B181-7168-4D59-9DF1-BA9933F2830EQ24650225-B9F83FC6-5C58-4040-9B25-C555544DA2BAQ26777882-79892364-865E-42B5-B549-E80B6E38CEC0Q26801053-6CAF2736-0427-43A3-8D0B-90D6034536F0Q27021266-D5C26D92-925B-427A-8B36-E3E0391AB012Q28118996-C4652763-685F-4F07-8B5B-49DB1BF49ADDQ28388563-A26FAC8C-02C9-4445-9A92-0675EF9B1985Q28584193-6ECA4CBD-1E2B-4C14-BC19-21D1F14A7354Q30276422-0656BA19-5380-469D-85F6-51E531854A7BQ30278790-BB6E1EB0-D162-4044-B219-2F0D74675717Q30395891-8C329D8F-2A92-417B-B474-89590BEFAFFEQ30408290-D5F33D21-A68C-492F-AB25-858BD6F3300DQ30493841-03FE2B89-EB4D-4D34-9CBE-50FBB8254DE5Q31142794-A21D3541-8923-4400-9451-D920D4EA4596Q31151086-BFF484F5-3C5D-465F-9EB0-ED467A2CB1FBQ33372690-9EFE9388-AECD-45E3-95E8-3F2B0F145C3DQ33697369-F81C6A70-5165-4745-A991-CF15DB55C723Q33721111-67D3C487-ACD0-48AA-8E11-A7966021B83FQ33740488-520723F5-9848-440B-B5E0-D317FEF0CC96Q33744631-3E4206C8-E47E-4B0C-A73E-F0623F09628CQ33820284-DD777C91-B0ED-4AD6-81E3-4E8C06D69427Q33870579-04CA6551-9C8E-4E59-AD2F-31C7F861166CQ34041280-1CA58400-683B-4D9D-B012-08E48DC5C6F4Q34042241-8487D5D8-C48B-4BEB-8860-3EE06B257737Q34062012-DBE7A587-8A80-4930-A38F-2A41A823ED8CQ34088885-D85864AF-7688-42CB-8542-23A7B028EADFQ34291456-D39D12A2-4B9F-4817-A5EF-57B2A16D6DE3Q34334192-902E1080-375F-4938-A56D-89F6CD21731BQ34334399-037C4FF3-782D-4B0F-BB1D-25DC030D5373Q34441744-97050186-EFE0-4F29-87B8-464BDDF05BACQ34446322-BBC4B3E0-229D-45D1-8467-FD47CDD867AFQ34518047-EC60D8F9-CF26-4936-AA0D-F444A51D38BBQ34575479-B8FD6C8C-750C-4FE5-BEEB-916E5C6CDC97Q34634316-D6D45470-0C16-47D5-B58C-7D16151100F2Q34650656-7E86F87E-97DB-4E8B-BFD4-D71E978416B7Q34682265-B68FD8DC-A493-4D93-AD3E-BFA45BC61543Q34715455-F78743D4-8D5F-42DA-AD0A-6427A9F61A4BQ34718996-FF463548-06A2-4133-8AFE-D2A72C221D1A
P2860
STAT3 as a central mediator of neoplastic cellular transformation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
STAT3 as a central mediator of neoplastic cellular transformation.
@ast
STAT3 as a central mediator of neoplastic cellular transformation.
@en
type
label
STAT3 as a central mediator of neoplastic cellular transformation.
@ast
STAT3 as a central mediator of neoplastic cellular transformation.
@en
prefLabel
STAT3 as a central mediator of neoplastic cellular transformation.
@ast
STAT3 as a central mediator of neoplastic cellular transformation.
@en
P1433
P1476
STAT3 as a central mediator of neoplastic cellular transformation.
@en
P2093
David A Frank
P304
P356
10.1016/J.CANLET.2006.10.017
P407
P577
2006-11-28T00:00:00Z