Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins
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Mutational analysis of the v-Rel dimerization interface reveals a critical role for v-Rel homodimers in transformationI kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motifIkappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaBLoss of IkappaB alpha-mediated control over nuclear import and DNA binding enables oncogenic activation of c-RelMultiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel.Mapping of a serine-rich domain essential for the transcriptional, antiapoptotic, and transforming activities of the v-Rel oncoprotein.Differential regulation of the inhibitor of apoptosis ch-IAP1 by v-rel and the proto-oncogene c-rel.The relocalization of v-Rel from the nucleus to the cytoplasm coincides with induction of expression of Ikba and nfkb1 and stabilization of I kappa B-alpha.Mutations in the DNA-binding and dimerization domains of v-Rel are responsible for altered kappa B DNA-binding complexes in transformed cellsEvolution of the oncogenic potential of v-rel: rel-induced expression of immunoregulatory receptors correlates with tumor development and in vitro transformationTransformation of avian fibroblasts overexpressing the c-rel proto-oncogene and a variant of c-rel lacking 40 C-terminal amino acids.In vivo evolution of c-rel oncogenic potential.Heterologous C-terminal sequences disrupt transcriptional activation and oncogenesis by p59v-rel.A mutant v-rel with increased ability to transform B lymphocytes.The v-rel oncogene promotes malignant T-cell leukemia/lymphoma in transgenic mice.The reverse two-hybrid system: a genetic scheme for selection against specific protein/protein interactions.PEST-dependent cytoplasmic retention of v-Rel by I(kappa)B-alpha: evidence that I(kappa)B-alpha regulates cellular localization of c-Rel and v-Rel by distinct mechanisms.IkappaBalpha overexpression delays tumor formation in v-rel transgenic mice.Identification of a C/EBP-Rel complex in avian lymphoid cells.An optimal range of transcription potency is necessary for efficient cell transformation by c-Rel to ensure optimal nuclear localization and gene-specific activation.
P2860
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P2860
Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins
@ast
Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins
@en
type
label
Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins
@ast
Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins
@en
prefLabel
Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins
@ast
Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins
@en
P2093
P2860
P356
P1476
Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins
@en
P2093
T A McKinsey
P2860
P304
P356
10.1128/MCB.13.3.1769
P407
P577
1993-03-01T00:00:00Z