Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction
about
Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinasesMultiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cellsThe full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptorsThe importance of the granulocyte-colony stimulating factor in oncologyActivating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signallingThe conserved box 1 motif of cytokine receptors is required for association with JAK kinasesInfluence of subunit combinations on signaling by receptors for oncostatin M, leukemia inhibitory factor, and interleukin-6Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerizationThe granulocyte colony-stimulating factor receptor supports erythroid differentiation in the absence of the erythropoietin receptor or Stat5.Myeloperoxidase gene expression and regulation by myeloid cell growth factors in normal and leukemic cells.Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis.Cytoplasmic domains of the common beta-chain of the GM-CSF/IL-3/IL-5 receptors that are required for inducing differentiation or clonal suppression in myeloid leukaemic cell lines.Dissection of c-Mpl and thrombopoietin function: studies of knockout mice and receptor signal transduction.Erythropoietin-induced cellular differentiation requires prolongation of the G1 phase of the cell cycle.Mutational analysis of a critical signaling domain of the human interleukin 4 receptor.Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietinCharacterization of mpl cytoplasmic domain sequences required for myeloproliferative leukemia virus pathogenicity.Erythropoietin receptor signals both proliferation and erythroid-specific differentiation.Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturationEstablishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival.Increased granulocyte colony-stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony-stimulating factor receptor mutation derived from a patient with severe congenital neutropenia.Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation.Two separate signal transducer and activator of transcription proteins regulate transcription of the serine proteinase inhibitor-3 gene in hepatic cells.Severe congenital neutropenias.Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation.Distinct signal transduction through the tyrosine-containing domains of the granulocyte colony-stimulating factor receptor.Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activationTyrosine residues in the granulocyte colony-stimulating factor (G-CSF) receptor mediate G-CSF-induced differentiation of murine myeloid leukemic (M1) cells.Activating mechanism of CNTF and related cytokines.Aberrant activation of JAK/STAT pathway components in response to G-CSF, interferon-alpha/beta and interferon-gamma in NFS-60 cells.Proline-rich sequence-mediated Jak2 association to the prolactin receptor is required but not sufficient for signal transduction.The biological features of multiple myeloma.The action of interleukin-2 receptor subunits defines a new type of signaling mechanism for hematopoietin receptors in hepatic cells and fibroblasts.The granulocyte colony-stimulating factor receptor and its role in disorders of granulopoiesis.G-CSF administration in a small-for-size liver model.Gain-of-function mutations in granulocyte colony-stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation.CSF3R and CALR mutations in paediatric myeloid disorders and the association of CSF3R mutations with translocations, including t(8; 21).
P2860
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P2860
Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Distinct regions of the human ...... oliferation and gene induction
@ast
Distinct regions of the human ...... oliferation and gene induction
@en
type
label
Distinct regions of the human ...... oliferation and gene induction
@ast
Distinct regions of the human ...... oliferation and gene induction
@en
prefLabel
Distinct regions of the human ...... oliferation and gene induction
@ast
Distinct regions of the human ...... oliferation and gene induction
@en
P2093
P2860
P356
P1476
Distinct regions of the human ...... oliferation and gene induction
@en
P2093
P2860
P304
P356
10.1128/MCB.13.4.2384
P407
P577
1993-04-01T00:00:00Z