Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants. - Wikidata - wikimedia - TriplyDB

Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.

Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.

http://www.wikidata.org/entity/Q36685124

about

Local innate immune responses in the vaccine adjuvant-injected muscle Oxidation by neutrophils-derived HOCl increases immunogenicity of proteins by converting them into ligands of several endocytic receptors involved in antigen uptake by dendritic cells and macrophages Phagolysosome Acidification is Required for Silica and Engineered Nanoparticle-induced Lysosome Membrane Permeabilization and Resultant NLRP3 Inflammasome Activity A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants.Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents.Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role.Odanacatib, A Cathepsin K-Specific Inhibitor, Inhibits Inflammation and Bone Loss Caused by Periodontal Diseases Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death.Effects of MF59 Adjuvant on Induction of Isotype-Switched IgG Antibodies and Protection after Immunization with T-Dependent Influenza Virus Vaccine in the Absence of CD4+ T Cells.NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx.Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures.Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis Licensing Adaptive Immunity by NOD-Like Receptors.Biphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cells Cysteine proteases in atherosclerosis.Yeast as a tool to explore cathepsin D function.Engineered nanomaterial-induced lysosomal membrane permeabilization and anti-cathepsin agents.Old and new adjuvants.Streptococcus oralis Induces Lysosomal Impairment of Macrophages via Bacterial Hydrogen Peroxide On the road to inflammation: linking lysosome disruption, lysosomal protease release and necrotic death of immune cells How inflammasomes inform adaptive immunity.Therapeutic effects of PADRE-BAFF autovaccine on rat adjuvant arthritis.Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation Complete lysosomal disruption: a route to necrosis, not to the inflammasome.Macrophage Recognition of Crystals and Nanoparticles.

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P2860

Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.

http://www.wikidata.org/entity/Q36685124

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

Cathepsin-mediated necrosis co ...... type 2)-associated adjuvants.

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JBC.M112.400655

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Journal of Biological Chemistry

P1476

Cathepsin-mediated necrosis co ...... type 2)-associated adjuvants.

@en

P2093

Bianca V Gapp

http://www.w3.org/2001/XMLSchema#string

Fayyaz S Sutterwala

http://www.w3.org/2001/XMLSchema#string

Felipe Diaz-Griffero

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Heriberto Lima

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Johanna A Joyce

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Jürgen Brojatsch

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Kartik Chandran

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Lee S Jacobson

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Michael F Goldberg

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Thijn R Brummelkamp

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P2860

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

Haploid genetic screens in human cells identify host factors used by pathogens

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Cytolysin-dependent escape of the bacterium from the phagosome is required but not sufficient for induction of the Th1 immune response against Listeria monocytogenes infection: distinct role of Listeriolysin O determined by cytolysin gene replacement

Anthrax lethal toxin-mediated killing of human and murine dendritic cells impairs the adaptive immune response

The Common vaccine adjuvant aluminum hydroxide up-regulates accessory properties of human monocytes via an interleukin-4-dependent mechanism

Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling

Functions of lysosomes

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

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7481-7491

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scholarly article

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10.1074/JBC.M112.400655

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11

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288

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2013-01-07T00:00:00Z

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