Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9. - Wikidata - wikimedia - TriplyDB

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

http://www.wikidata.org/entity/Q36692987

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Dynamic Viral Glycoprotein Machines: Approaches for Probing Transient States That Drive Membrane Fusion Recent strategies targeting HIV glycans in vaccine design Structural insights on the role of antibodies in HIV-1 vaccine and therapy Designing synthetic vaccines for HIV HIV-1 neutralizing antibodies: understanding nature's pathways Antibodies in HIV-1 vaccine development and therapy HIV broadly neutralizing antibody targets Glycotherapy: new advances inspire a reemergence of glycans in medicine A Chimeric HIV-1 gp120 Fused with Vaccinia Virus 14K (A27) Protein as an HIV Immunogen A saposin-lipoprotein nanoparticle system for membrane proteins.Antigenic properties of the human immunodeficiency virus envelope glycoprotein gp120 on virions bound to target cells Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120 Thermodynamic Signatures of the Antigen Binding Site of mAb 447–52D Targeting the Third Variable Region of HIV-1 gp120 Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign Receptor mimicry by antibody F045–092 facilitates universal binding to the H3 subtype of influenza virus Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers.Antiviral Therapy by HIV-1 Broadly Neutralizing and Inhibitory Antibodies Targeting host-derived glycans on enveloped viruses for antibody-based vaccine design HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies Computational prediction of broadly neutralizing HIV-1 antibody epitopes from neutralization activity data HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies.Mutations in HIV-1 envelope that enhance entry with the macaque CD4 receptor alter antibody recognition by disrupting quaternary interactions within the trimer.HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual.Antigenic and 3D structural characterization of soluble X4 and hybrid X4-R5 HIV-1 Env trimers Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure.Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters.HIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing Antibodies.

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Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

http://www.wikidata.org/entity/Q36692987

description

2013 nî lūn-bûn

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2013年论文

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name

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

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Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

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type

label

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

@ast

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

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prefLabel

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

@ast

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

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PNAS.1217537110

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Proceedings of the National Academy of Sciences of the United States of America

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Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

@en

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Albert Cupo

http://www.w3.org/2001/XMLSchema#string

Andre J Marozsan

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Andrew B Ward

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C Richter King

http://www.w3.org/2001/XMLSchema#string

Charles D Murin

http://www.w3.org/2001/XMLSchema#string

Ian A Wilson

http://www.w3.org/2001/XMLSchema#string

John P Moore

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Michael J Caulfield

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Per Johan Klasse

http://www.w3.org/2001/XMLSchema#string

Rogier W Sanders

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P2860

Structural mechanism of trimeric HIV-1 envelope glycoprotein activation

NIH Image to ImageJ: 25 years of image analysis

Determination of domain structure of proteins from X-ray solution scattering

The Antibody Response against HIV-1

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Molecular architecture of native HIV-1 gp120 trimers

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

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4351-4356

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scholarly article

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10.1073/PNAS.1217537110

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11

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110

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Jean-Philippe Julien

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2013-02-20T00:00:00Z

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235682220

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23426631

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