Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains
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The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3A cellular repressor of E1A-stimulated genes that inhibits activation by E2FTwo domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repressionPhosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation functionEffects of B-Myb on gene transcription: phosphorylation-dependent activity ans acetylation by p300Adenovirus E1A243 disrupts the ATF/CREB-YY1 complex at the mouse c-fos promoter.Identification of a novel E1A response element in the mouse c-fos promoter.AR1 is an integral part of the adenovirus type 2 E1A-CR3 transactivation domain.E2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP.The CtBP binding domain in the adenovirus E1A protein controls CR1-dependent transactivation.The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation.Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A.A TEF-1-independent mechanism for activation of the simian virus 40 (SV40) late promoter by mutant SV40 large T antigensInduction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesisCREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation.Oncogenic capacity of the E2F1 geneThe viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B.Functional importance of complex formation between the retinoblastoma tumor suppressor family and adenovirus E1A proteins as determined by mutational analysis of E1A conserved region 2The E1A products of oncogenic adenovirus serotype 12 include amino-terminally modified forms able to bind the retinoblastoma protein but not p300A complex promoter element mediates transactivation of the human proliferating cell nuclear antigen promoter by the 243-residue adenovirus E1A oncoproteinTGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein.Extreme N terminus of E1A oncoprotein specifically associates with a new set of cellular proteins.E1A represses apolipoprotein AI enhancer activity in liver cells through a pRb- and CBP-independent pathway.The human papillomavirus type 16 E7 protein complements adenovirus type 5 E1A amino-terminus-dependent transactivation of adenovirus type 5 early genes and increases ATF and Oct-1 DNA binding activity.Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes.Complementary functions of E1a conserved region 1 cooperate with conserved region 3 to activate adenovirus serotype 5 early promoters.Repression of RNA polymerase III transcription by adenovirus E1A.An adenovirus E1A transcriptional repressor domain functions as an activator when tethered to a promoterThe steroid receptor co-activator-1 (SRC-1) potentiates TGF-beta/Smad signaling: role of p300/CBP.Adenovirus-E1A proteins transform cells by sequestering regulatory proteins.Role of p300, a transcriptional coactivator, in signalling of TGF-beta.The effect of E1A transfection on MMP-9 expression and metastatic potential.Adenovirus type 5 early region 1B 156R protein promotes cell transformation independently of repression of p53-stimulated transcription.Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators.Core promoter involvement in the induction of rat ornithine decarboxylase by phorbol esters.Identification of the transactivation domain of the transcription factor Sox-2 and an associated co-activator.
P2860
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P2860
Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Promoter-specific trans-activa ...... involves separate E1A domains
@ast
Promoter-specific trans-activa ...... involves separate E1A domains
@en
type
label
Promoter-specific trans-activa ...... involves separate E1A domains
@ast
Promoter-specific trans-activa ...... involves separate E1A domains
@en
prefLabel
Promoter-specific trans-activa ...... involves separate E1A domains
@ast
Promoter-specific trans-activa ...... involves separate E1A domains
@en
P2093
P2860
P356
P1476
Promoter-specific trans-activa ...... involves separate E1A domains
@en
P2093
P2860
P304
P356
10.1128/MCB.12.10.4391
P407
P577
1992-10-01T00:00:00Z