The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions
about
Metabolic influences that regulate dendritic cell function in tumorsTargeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potentialAllogeneic lymphocyte-licensed DCs expand T cells with improved antitumor activity and resistance to oxidative stress and immunosuppressive factorsStimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer.CD70 and IFN-1 selectively induce eomesodermin or T-bet and synergize to promote CD8+ T-cell responses.Dual function of CD70 in viral infection: modulator of early cytokine responses and activator of adaptive responses.Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses.Promotion of a subdominant CD8 T cell response during murine gammaherpesvirus 68 infection in the absence of CD4 T cell helpProlonged antigen presentation by immune complex-binding dendritic cells programs the proliferative capacity of memory CD8 T cells.Transplantation tolerance: from theory to clinic.Concurrent interaction of DCs with CD4(+) and CD8(+) T cells improves secondary CTL expansion: It takes three to tango.FoxO3 is a negative regulator of primary CD8+ T-cell expansion but not of memory formationCD8+ T Cell Fate and Function Influenced by Antigen-Specific Virus-Like Nanoparticles Co-Expressing Membrane Tethered IL-2.Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cellsCD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus.CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive StimuliCD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza.Therapeutic applications of TRAIL receptor agonists in cancer and beyond.CIMT 2015: The right patient for the right therapy - Report on the 13th annual meeting of the Association for Cancer ImmunotherapyImmediate Dysfunction of Vaccine-Elicited CD8+ T Cells Primed in the Absence of CD4+ T Cells.Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens.The contextual role of TNFR family members in CD8(+) T-cell control of viral infections.Regulation of hematopoietic and leukemic stem cells by the immune system.The importance of co-stimulation in the orchestration of T helper cell differentiation.Therapeutic targeting of CD70 and CD27.Lymph node - an organ for T-cell activation and pathogen defense.Ikaros imposes a barrier to CD8+ T cell differentiation by restricting autocrine IL-2 production.A CD40/CD40L feedback loop drives the breakdown of CD8(+) T-cell tolerance following depletion of suppressive CD4(+) T cells.Dendritic cells and isolevuglandins in immunity, inflammation, and hypertension.Dendritic Cells In Hepatitis and Liver Transplantation.Oligoclonal CD8+ T cells play a critical role in the development of hypertension.CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection.Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells.CD27 costimulation contributes substantially to the expansion of functional memory CD8(+) T cells after peptide immunization.Novel Adjuvant Based on the Pore-Forming Protein Sticholysin II Encapsulated into Liposomes Effectively Enhances the Antigen-Specific CTL-Mediated Immune Response.CD70 encoded by modified vaccinia virus Ankara enhances CD8 T cell dependent protective immunity in MHC class II-deficient mice.Cooperation of CD4+ T cells and CD8+ T cells and release of IFN-γ are critical for antileukemia responses of recipient mice treated by microtransplantation.A Brief Introduction into the Renin-Angiotensin-Aldosterone System: New and Old Techniques.
P2860
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P2860
The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
The CD4⁺ T-cell help signal is ...... lls via CD27-CD70 interactions
@ast
The CD4⁺ T-cell help signal is ...... lls via CD27-CD70 interactions
@en
type
label
The CD4⁺ T-cell help signal is ...... lls via CD27-CD70 interactions
@ast
The CD4⁺ T-cell help signal is ...... lls via CD27-CD70 interactions
@en
prefLabel
The CD4⁺ T-cell help signal is ...... lls via CD27-CD70 interactions
@ast
The CD4⁺ T-cell help signal is ...... lls via CD27-CD70 interactions
@en
P2093
P2860
P356
P1476
The CD4⁺ T-cell help signal is ...... lls via CD27-CD70 interactions
@en
P2093
Hideo Yagita
Jannie Borst
Ramon Arens
Sonia Feau
Zacarias Garcia
P2860
P2888
P356
10.1038/NCOMMS1948
P407
P577
2012-07-10T00:00:00Z