Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.
about
High-throughput screening to identify inhibitors of lysine demethylasesSurgery in the era of the 'omics revolutionInhibition of the histone demethylase Kdm5b promotes neurogenesis and derepresses Reln (reelin) in neural stem cells from the adult subventricular zone of mice.An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cellsStructural analysis of human KDM5B guides histone demethylase inhibitor developmentCell-based assays to support the profiling of small molecules with histone methyltransferase and demethylase modulatory activityProstate Cancer: Epigenetic Alterations, Risk Factors, and TherapyHistone demethylase lysine demethylase 5B in development and cancerHistone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genesAn high-throughput in vivo screening system to select H3K4-specific histone demethylase inhibitorsJARID1B Expression Plays a Critical Role in Chemoresistance and Stem Cell-Like Phenotype of Neuroblastoma CellsRSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In VivoScreen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistanceHistone demethylase RBP2 is critical for breast cancer progression and metastasis.Chromatin and oxygen sensing in the context of JmjC histone demethylasesTargeting histone lysine demethylases - progress, challenges, and the futureIdentification of small molecule modulators of gene transcription with anticancer activity.Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy.Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells.ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential.Knockout of Angiotensin AT2 receptors accelerates healing but impairs qualityTranscriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia.Depletion of histone demethylase KDM5B inhibits cell proliferation of hepatocellular carcinoma by regulation of cell cycle checkpoint proteins p15 and p27.Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse CompoundsAn easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targetingHistone modifications: implications in renal cell carcinoma.Extended self-renewal and accelerated reprogramming in the absence of Kdm5b.Recent advances in the ARID family: focusing on roles in human cancer.KDM5 lysine demethylases are involved in maintenance of 3'UTR length.Histone demethylases set the stage for cancer metastasis.Small molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases.Pre-clinical studies of epigenetic therapies targeting histone modifiers in lung cancer.Chromatin modifiers and the promise of epigenetic therapy in acute leukemiaEpigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.Histone H3K4 trimethylation: dynamic interplay with pre-mRNA splicing.Targeting epigenetic regulators for cancer therapy: modulation of bromodomain proteins, methyltransferases, demethylases, and microRNAs.Critical Evaluation of Native Electrospray Ionization Mass Spectrometry for Fragment-Based Screening.Histone Lysine Demethylase Inhibitors.A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine.
P2860
Q26851462-E30965DB-BD3E-42D0-8147-239C887E61B7Q26852061-000281A5-08FA-4A2D-90D4-B43EB6AC14F4Q27305235-D30E0154-2F95-4B9F-935E-6536D4BDC87DQ27704919-062B5CDB-7539-4AEF-968D-48CBEDF6CD88Q27704921-A4B483AE-DD68-4702-BE6C-543294FC4FEEQ28070111-9A39B23C-FA51-46AA-899D-F4AAA4D83E9EQ28073470-7DC367D8-DAD9-4711-B241-925956FD2960Q28076257-F7EBBB5D-6FD8-4E9E-B699-4C583C80C7A2Q28511595-66F62ECF-EF0F-49E9-AE5C-DEEF10E8E3D4Q28539276-D2B4B7CA-7AB6-4EF9-8997-D93A800C3ABCQ28547102-5687962B-E322-4246-845C-0115E70B4E4CQ28548423-FB4B8120-17F6-4D21-B02D-28237DF2DBABQ28818255-A474B0C0-E28A-4CAD-8DCD-33C61C0FA4DCQ33582497-3402F051-8553-4070-9A89-8A9E1D7429D7Q34103385-A7EE8FF2-AF68-46BA-B57D-F95885E1F335Q34421279-0BB9408D-3D98-4EBE-ADFE-1FF03179D98FQ34576203-B81961AD-2F21-4233-96D6-72D8FCD9A5B3Q35228976-437B2133-9F5F-4EC6-915B-9D7CA2C561F7Q35671583-562844D4-7834-4F85-A64B-221C63BA5529Q35801707-DB67368D-5B84-401B-860E-5ECB3BB13547Q35824823-17EBF171-9182-43B3-9E78-96961550BC6BQ36460819-6987A1E1-806F-4CF6-B586-F068C3BC7575Q36594686-FFA48DD1-3D29-4EDA-94B9-F9ACBD2D09A6Q36616276-1A7CE5F0-5416-4FD9-9548-DD649F059108Q37120958-8FBBBE2C-4BA1-45CB-BDBC-86EBC6F98BC7Q37401076-EE9A0D5D-2427-4417-B7BD-153679847EE5Q37414110-78F1FD9E-EF77-4D0B-8161-AE58A49052E4Q37469466-33A757C8-9790-449A-8A10-230C96F130FBQ37601383-3048C73C-DD62-4159-BB40-AF69586DFFA5Q37603840-AD99A4CD-7DD0-4C35-9BEC-AB0F23EF4661Q38103230-F7E83E84-1CA7-40B8-8721-79ECF1419503Q38132808-7772C676-7334-4AF7-A998-81CC20B06EC8Q38140920-1AC2BE7A-A586-40DE-B2CE-396D37FAB9B3Q38194444-581238A5-0AF2-4452-9ACD-5A57275331F1Q38233723-E336B078-A4CD-4C10-9E3B-4B59BE195188Q38583533-A3F9B388-DB5F-4CA2-9D8C-942502EB9B7BQ38707876-40F43696-61FD-4AB0-8619-9A6EBD0F394EQ38724133-5637DFFE-9FD3-4453-BAAC-4B88BAAECE68Q39066287-348986D4-6068-4F92-B803-F050CE43DA61Q47251165-A460AB33-ECCE-4507-B2EA-9A67117BF852
P2860
Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Identification of small molecu ...... sitive high throughput screen.
@ast
Identification of small molecu ...... sitive high throughput screen.
@en
type
label
Identification of small molecu ...... sitive high throughput screen.
@ast
Identification of small molecu ...... sitive high throughput screen.
@en
prefLabel
Identification of small molecu ...... sitive high throughput screen.
@ast
Identification of small molecu ...... sitive high throughput screen.
@en
P2093
P2860
P356
P1476
Identification of small molecu ...... nsitive high throughput screen
@en
P2093
Alan J Tackett
Denton Hoyer
Jane S Merkel
Joyce Sayegh
Lauren P Blair
Michael Norcia
Mike Ran Zou
P2860
P304
P356
10.1074/JBC.M112.419861
P407
P577
2013-02-13T00:00:00Z