Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision.
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Endonuclease V cleaves at inosines in RNAIdentification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNAAPE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.Human AP endonuclease 1: a potential marker for the prediction of environmental carcinogenesis riskEmerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical exampleAPE1 incision activity at abasic sites in tandem repeat sequencesGenetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activityIdentification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic miceIntrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?Regulatory mechanisms of RNA function: emerging roles of DNA repair enzymes.Base excision repair: a critical player in many gamesImpact of abasic site orientation within nucleosomes on human APE1 endonuclease activity.Nucleolin and nucleophosmin: nucleolar proteins with multiple functions in DNA repair.Small molecule inhibitors of DNA repair nuclease activities of APE1.An assay for RNA oxidation induced abasic sites using the Aldehyde Reactive ProbeAltered endoribonuclease activity of apurinic/apyrimidinic endonuclease 1 variants identified in the human populationBase excision repair: contribution to tumorigenesis and target in anticancer treatment paradigmsImpact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder.Characterization of the endoribonuclease active site of human apurinic/apyrimidinic endonuclease 1.Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice.The structural location of DNA lesions in nucleosome core particles determines accessibility by base excision repair enzymesAltered DNA base excision repair profile in brain tissue and blood in Alzheimer's diseaseSynthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression.Nucleic acid binding activity of human Cockayne syndrome B protein and identification of Ca(2+) as a novel metal cofactorHuman apurinic/apyrimidinic endonuclease 1.SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements.The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once.RNA-cleaving properties of human apurinic/apyrimidinic endonuclease 1 (APE1).Dual roles of DNA repair enzymes in RNA biology/post-transcriptional control.Quality control of chemically damaged RNA.A comparative study of recombinant mouse and human apurinic/apyrimidinic endonucleaseMammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.Human AP endonuclease inefficiently removes abasic sites within G4 structures compared to duplex DNA.Slow repair of lipid peroxidation-induced DNA damage at p53 mutation hotspots in human cells caused by low turnover of a DNA glycosylaseConformational transitions in human AP endonuclease 1 and its active site mutant during abasic site repair.Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin).Accelerated processing of solitary and clustered abasic site DNA damage lesions by APE1 in the presence of aqueous extract of Ganoderma lucidum.
P2860
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P2860
Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Characterization of abasic end ...... e context on AP site incision.
@ast
Characterization of abasic end ...... e context on AP site incision.
@en
type
label
Characterization of abasic end ...... e context on AP site incision.
@ast
Characterization of abasic end ...... e context on AP site incision.
@en
prefLabel
Characterization of abasic end ...... e context on AP site incision.
@ast
Characterization of abasic end ...... e context on AP site incision.
@en
P2093
P2860
P1476
Characterization of abasic end ...... e context on AP site incision.
@en
P2093
Brian R Berquist
Daniel R McNeill
David M Wilson
P2860
P356
10.1016/J.JMB.2008.03.053
P407
P577
2008-04-03T00:00:00Z