about
The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECsEpac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migrationRecent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Cyclic AMP accelerates calcium waves in pancreatic acinar cellsPhosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC)The future of EPAC-targeted therapies: agonism versus antagonismEpac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors.Epac and PKA: a tale of two intracellular cAMP receptors.Broad-scale phosphoprotein profiling of beta adrenergic receptor (β-AR) signaling reveals novel phosphorylation and dephosphorylation eventsActivation of a cyclic amp-guanine exchange factor in hepatocytes decreases nitric oxide synthase expression.The cyclic AMP effector Epac integrates pro- and anti-fibrotic signalsSignal transduction underlying the control of urinary bladder smooth muscle tone by muscarinic receptors and beta-adrenoceptorsEPAC proteins transduce diverse cellular actions of cAMP.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.Regulation of the inflammatory response of vascular endothelial cells by EPAC1.Signaling to cardiac hypertrophy: insights from human and mouse RASopathies.Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.Kinome-wide screening of HER2+ breast cancer cells for molecules that mediate cell proliferation or sensitize cells to trastuzumab therapy.The cAMP effector EPAC activates Elk1 transcription factor in prostate smooth muscle, and is a minor regulator of α1-adrenergic contraction.Activation by Ca2+/calmodulin of an exogenous myosin light chain kinase in mouse arteries.Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery.Depotentiation of intact rat cardiac muscle unmasks an Epac-dependent increase in myofilament Ca(2+) sensitivity.The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation.Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Epac and the cardiovascular system.
@ast
Epac and the cardiovascular system.
@en
type
label
Epac and the cardiovascular system.
@ast
Epac and the cardiovascular system.
@en
prefLabel
Epac and the cardiovascular system.
@ast
Epac and the cardiovascular system.
@en
P2093
P1476
Epac and the cardiovascular system.
@en
P2093
Carsten Sand
Karl H Jakobs
Martina Schmidt
Paschal A Oude Weernink
P304
P356
10.1016/J.COPH.2006.10.004
P577
2007-02-02T00:00:00Z