IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds
about
VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancerVRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signalingSignaling threshold regulation by the Ras effector IMP.The Biological Function of the Prion Protein: A Cell Surface Scaffold of Signaling ModulesSignal control through Raf: in sickness and in health.Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount.Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.Central catalytic domain of BRAP (RNF52) recognizes the types of ubiquitin chains and utilizes oligo-ubiquitin for ubiquitylation.Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of RasBRAP-2 promotes DNA damage induced germline apoptosis in C. elegans through the regulation of SKN-1 and AKT-1.BRAP binds KSR1:MARK3BRAP binds RAS:GTPBRAP autoubiquitinatesCCDC178 promotes hepatocellular carcinoma metastasis through modulation of anoikis.
P2860
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P2860
IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
IMP modulates KSR1-dependent m ...... vation and response thresholds
@ast
IMP modulates KSR1-dependent m ...... vation and response thresholds
@en
type
label
IMP modulates KSR1-dependent m ...... vation and response thresholds
@ast
IMP modulates KSR1-dependent m ...... vation and response thresholds
@en
prefLabel
IMP modulates KSR1-dependent m ...... vation and response thresholds
@ast
IMP modulates KSR1-dependent m ...... vation and response thresholds
@en
P2093
P2860
P356
P1476
IMP modulates KSR1-dependent m ...... vation and response thresholds
@en
P2093
Chiyuan Chen
Michael A White
Robert E Lewis
P2860
P304
12789-12796
P356
10.1074/JBC.M709305200
P407
P577
2008-03-10T00:00:00Z