Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases. - Wikidata - wikimedia - TriplyDB

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.

http://www.wikidata.org/entity/Q36751576

about

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases Similar effects of all WNK3 variants on SLC12 cotransporters WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway Renal and brain isoforms of WNK3 have opposite effects on NCCT expression Molecular regulation of NKCC2 in the thick ascending limb Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation Thick ascending limb: the Na(+):K (+):2Cl (-) co-transporter, NKCC2, and the calcium-sensing receptor, CaSR cAMP stimulates apical exocytosis of the renal Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in the thick ascending limb: role of protein kinase A Regulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2 Behavioral analysis of Ste20 kinase SPAK knockout mice.Molecular pathophysiology of Bartter's and Gitelman's syndromes.Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression Phosphorylation and transport in the Na-K-2Cl cotransporters, NKCC1 and NKCC2A, compared in HEK-293 cells.Anion-sensitive regions of L-type CaV1.2 calcium channels expressed in HEK293 cells.Rare mutations in renal sodium and potassium transporter genes exhibit impaired transport function.Mechanism of salt-sensitive hypertension: focus on adrenal and sympathetic nervous systems Chloride channels: often enigmatic, rarely predictable.Molecular components of signal amplification in olfactory sensory cilia.Hypochloraemia is strongly and independently associated with mortality in patients with chronic heart failure.KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1).Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule.MAL/VIP17, a new player in the regulation of NKCC2 in the kidney Short forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage.Thick ascending limb of the loop of Henle.The WNKs: atypical protein kinases with pleiotropic actions.Recent advances in distal tubular potassium handling High salt differentially regulates surface NKCC2 expression in thick ascending limbs of Dahl salt-sensitive and salt-resistant rats STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy.Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume A mathematical model of rat proximal tubule and loop of Henle.KCNJ10 (Kir4.1) is expressed in the basolateral membrane of the cortical thick ascending limb.Regulatory activation is accompanied by movement in the C terminus of the Na-K-Cl cotransporter (NKCC1).NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus.

P2860

Q24297671-DC7A5646-52BA-4F93-A110-142D952898E8 Q24304374-36DAC2B4-57C0-4CE5-B382-7DD7C0B5556F Q24310130-56DD6525-5234-4735-BC7F-7531A6D46D75 Q24311569-7A61427E-60C5-4535-8660-D7AC31E8489C Q24623288-70CEFDC7-5E8F-4CDE-8747-6B623F00E190 Q24646108-701305AB-231B-4790-9509-2990B2681677 Q24648927-1782DFF7-FBC9-4276-A8C2-127FE151E45A Q24651730-2EE9FDCA-2D81-4EF8-99E2-41CC0C07A44F Q26853028-8995181F-2545-4FB6-86B8-22087D9179F8 Q27683663-DA89E8ED-D819-4D7D-A1B6-F3A24FBACD0C Q28299702-7CC1A2E2-BFF5-44EC-98F6-4AF31F4C5050 Q28570785-F9283C73-1FF5-4C22-B970-B62C0C98B0E7 Q28593760-4A279AF7-03F7-438F-99B4-334DF76A1B79 Q30475980-3F93187C-56DD-4F84-891E-1BB91FE082BB Q30487704-1A201D1D-5F5B-45D8-8C56-2A78911CAF9E Q30558974-3A0782FC-4655-4584-AF19-FDB43D7181A4 Q31004742-95591277-F933-4ACA-8C62-7936508A8C6B Q33523280-A11635BC-497B-4958-A170-3135E25CDCB2 Q33557328-37DB773A-328F-453A-9E56-F21EE7CC4B76 Q33660709-3A2DE424-125A-4642-ADE9-3C2124938423 Q33775731-EC8404EA-808A-43A4-BB2B-429AA9696939 Q33778505-4360E1B8-07D8-4159-B9FF-A1A1D902BFCE Q33799953-69FFE53D-EB27-420E-AEAF-A5913C7E3F77 Q34060743-81A8F5B2-7FED-4DEB-86CA-FC40C0D09D9A Q34249011-BA87487D-4FFE-4D88-AF6D-5AD350ACD8B8 Q34313572-5EE53C86-B101-4655-AFFC-3098F18F7E44 Q34355791-C848807A-9FE8-45B4-8F9E-CBE353C2EAE5 Q34455234-2743DB9A-27ED-4BE4-8E4B-04775AEAD1BC Q34560188-04E27018-E9E4-4A4A-A2AE-711679068A30 Q34784068-D8489BCD-099E-413B-8932-6C59EF6EFDB5 Q34979687-FA117475-EADB-42E3-AEDC-D323809E3654 Q34994824-A39A57C6-96F3-492E-9835-55791747C5F9 Q35095908-C68FDB0C-0AF1-4169-BAC1-7CE4E39EAE03 Q35543284-BF3B6446-40BA-4A02-A357-A4184C4B7698 Q35622466-B16A2A26-E7B9-4A84-AC4B-881B22B1E138 Q35671836-379A1674-9722-44A9-BB79-1423DB01DCFE Q35694084-B54B7479-AA64-4317-8A70-5797EAE1463C Q35771348-DCB9E8C8-BC87-4061-82AF-426B12920F45 Q35900778-E18C6103-F5B7-40BF-B286-2DE948C7CBB6 Q36003108-B0B3F617-943E-4DB1-B04D-261563826A7A

P2860

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.

http://www.wikidata.org/entity/Q36751576

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

2008年论文

@zh

2008年论文

@zh-cn

name

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.

@en

type

label

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.

@en

prefLabel

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.

@en

P1433

Q36751576-C075D56E-2B25-4828-BD7C-29022DC1D31E

P1476

Q36751576-CFFFC573-2FF6-4320-81C3-20B2070E9AF4

P2093

Q36751576-0392BE4B-2E57-4F07-86F1-45EE7575C24C

Q36751576-03A97AFD-E79B-4EE5-97B0-3F03BC600E21

Q36751576-1BADA3CF-60FB-4D2E-B5FE-E8DC82283982

Q36751576-1F4F9929-3234-4DD7-BA97-BEF3DB83BFCC

Q36751576-257BC8B4-6DCC-4718-B153-4540B201011F

Q36751576-29EE3C27-19B8-4863-941F-5A113B711840

Q36751576-370FFA3F-118A-42D8-A603-E95C3557B618

Q36751576-6773400C-8886-45CD-8C9C-6CACBB56517D

Q36751576-B7593F1D-7ED3-4F20-B5AC-D37D6E87C5A9

Q36751576-C1D78BAF-5052-4FE6-88F8-749286DB874E

P2860

Q36751576-0185C29C-D664-4A76-9435-FCA62B7098AA

Q36751576-045074DE-6577-46F4-8F57-0F13C14E8974

Q36751576-05EAD14F-4236-41CD-B5D9-1ACC37A3965D

Q36751576-06C4978D-307A-4A1D-A0C1-8CE350DBE4AB

Q36751576-0D11C3C2-256B-4778-BBC5-001495C6F450

Q36751576-0DD38D0F-3FAF-48F6-9708-13D618F05DA0

Q36751576-0E22BB4D-B744-42A6-8E0E-735B092590BD

Q36751576-0FF0C40D-519F-4B97-A9A2-C70FF5E66407

Q36751576-191534AE-7FBD-4189-8FC3-AFB6F0DA5DEF

Q36751576-2749B84A-CFE4-4BB8-890A-C628DAF7EB51

P304

Q36751576-88749BED-A7C0-48BC-B585-7BD2CD20FCE4

P31

Q36751576-75C194BF-B6C8-4041-9D7B-9D9F294F1E4D

P356

Q36751576-7B83521B-ED87-46E9-AC04-640D8C6E4B95

P407

Q36751576-C6D7299D-0C1D-409C-85A0-336C8F4A329C

P433

Q36751576-DEDD80DB-BECB-4E00-9690-C1DC54DEA0B0

P478

Q36751576-E4D5D1EA-3927-4CEA-BD3C-A02581FE8C83

P577

Q36751576-9300F5EF-DE0E-4F28-9D44-8EB0A7D7CA13

P5875

Q36751576-0E39A86D-BE8C-4DA5-9745-5716204D5C91

P698

Q36751576-D880727C-48F2-4EC2-9156-B38C9E7327C1

P932

Q36751576-7E0F990A-1102-4578-B3D5-0536CD79F3E1

P356

PNAS.0802966105

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.

@en

P2093

Diana Pacheco-Alvarez

http://www.w3.org/2001/XMLSchema#string

Eva Muñoz

http://www.w3.org/2001/XMLSchema#string

Gabriela Michel

http://www.w3.org/2001/XMLSchema#string

Gerardo Gamba

http://www.w3.org/2001/XMLSchema#string

Ignacio Gimenez

http://www.w3.org/2001/XMLSchema#string

José Ponce-Coria

http://www.w3.org/2001/XMLSchema#string

Kristopher T Kahle

http://www.w3.org/2001/XMLSchema#string

Norma A Bobadilla

http://www.w3.org/2001/XMLSchema#string

Norma Vazquez

http://www.w3.org/2001/XMLSchema#string

Paola de Los Heros

http://www.w3.org/2001/XMLSchema#string

P2860

Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family

WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis

Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter

Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1)

Embryonic epithelial membrane transporters

Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase

Functional properties of the apical Na+-K+-2Cl- cotransporter isoforms

The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion

P304

8458-8463

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0802966105

http://www.w3.org/2001/XMLSchema#string

P407

P433

24

http://www.w3.org/2001/XMLSchema#string

P478

105

http://www.w3.org/2001/XMLSchema#string

P577

2008-06-11T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5305864

http://www.w3.org/2001/XMLSchema#string

P698

18550832

http://www.w3.org/2001/XMLSchema#string

P932

2448858

http://www.w3.org/2001/XMLSchema#string