Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability.
about
Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins--identification of additional interacting regions14-3-3 activation of DNA binding of p53 by enhancing its association into tetramersQuaternary structures of tumor suppressor p53 and a specific p53 DNA complexConsensus protein designElectrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomicsCrystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutationsTargeted rescue of a destabilized mutant of p53 by an in silico screened drugStabilising the DNA-binding domain of p53 by rational design of its hydrophobic coreInteraction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 TetramerAcetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentrationPUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosisStructure of p73 DNA-binding domain tetramer modulates p73 transactivationExperimental evidence for the thermophilicity of ancestral lifeStructures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescueThe consensus-based approach for gene/enzyme replacement therapies and crystallization strategies: the case of human alanine-glyoxylate aminotransferaseSpecific recognition of p53 tetramers by peptides derived from p53 interacting proteinsSolution structure and binding specificity of the p63 DNA binding domainStructures of closed and open conformations of dimeric human ATMThe design of a hyperstable mutant of the Abp1p SH3 domain by sequence alignment analysisDesign of highly stable functional GroEL minichaperones.An Integrated Mass Spectrometry Based Approach to Probe the Structure of the Full-Length Wild-Type Tetrameric p53 Tumor Suppressor.Meet me halfway: when genomics meets structural bioinformatics.Structural and dynamic properties that govern the stability of an engineered fibronectin type III domainComputational method to reduce the search space for directed protein evolution.In vitro evolution of thermostable p53 variantsSolution structure of p53 core domain: structural basis for its instability.Consensus design of repeat proteins.Stability of the core domain of p53: insights from computer simulations.Predicting positive p53 cancer rescue regions using Most Informative Positive (MIP) active learning.Conservation of DNA-binding specificity and oligomerisation properties within the p53 family.Optimization algorithms for functional deimmunization of therapeutic proteins.Consensus protein design without phylogenetic biasSCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53Ensemble-based computational approach discriminates functional activity of p53 cancer and rescue mutants.Roles of mutation and recombination in the evolution of protein thermodynamicsStrategies for manipulating the p53 pathway in the treatment of human cancer.Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.Stabilizing proteins from sequence statistics: the interplay of conservation and correlation in triosephosphate isomerase stability.A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition.
P2860
Q24299141-4D464B97-48B8-450B-BD85-F283D095977CQ24315405-93A8384F-EC27-443F-96F4-A942681BEAFFQ24681633-05C7BC64-A96A-4845-AC08-8900B80AF38BQ26748100-BE777E14-1B1F-4974-85DF-D38AB0DADDEAQ26822552-0576BFFA-71D7-4CA1-ABDC-F42B05B7F4A4Q27642314-F1EE447D-6317-4168-8348-4CE45D1DEC24Q27651295-1C673298-0BCC-4362-99E0-6B1ACA660CCBQ27655864-B20D3E93-21F0-4CD4-9A1F-A649E2BA861BQ27667399-B861BD46-4074-4B55-B743-D7CC9D4B9DC1Q27667596-164B51E9-2B0F-43C6-B2B0-DFDAB7417E30Q27675952-FC443B8B-A2F4-4223-9C7D-AE965A719503Q27678316-3087762B-D2E5-4626-8043-CAE70ED76461Q27678677-2812BA19-9A25-407B-B5B8-1C2BE4426613Q27680171-78EFC8D0-8335-40AB-9E52-1D82D8BE96CFQ27690792-3063C840-B2A5-4E4F-A8CD-8A4CB01FE255Q28484034-2C121622-2151-4633-9E77-85DE1044CBBBQ28833410-F0ECA1FD-98E0-4098-B4DA-52D1ED97170CQ29994717-AF9A1279-3A47-4F0E-A964-CEE701C14BA6Q30168443-969932D1-FB8F-47CF-B9D6-BFD8C84D7CBDQ30323239-B8E387CE-8699-44DE-857C-4340ABB07F94Q30395774-6A1B11C3-EC12-4287-900A-6F562B9C7FABQ30400158-CA3AD930-3A1B-4846-9ACC-70F345FE34C2Q30620600-F544E108-098B-4098-A164-8E04F48105FEQ30660873-A78A8CE3-2EEC-4A35-8066-49241C3F5186Q30672288-0A8ADD12-F4CB-489E-A7FD-9A1D3A961603Q31031898-DC2DFB31-6089-4697-B8B6-816439B82ABEQ33197434-3D90FD87-7921-4112-BBFE-2351FCAEDC95Q33322204-9D5C5D72-5845-4BE1-A3CA-F6FDEF4FB530Q33503650-00B3E474-1395-4733-A9A2-10C084D054A4Q33520529-C0F0139E-B643-4C06-A607-11A37B217FF1Q33551448-9C5EE64B-FA6F-4A9A-BF46-AA4DD4587AD5Q33569414-C0BDFEDC-D815-436E-A011-6B8E88BCBA7CQ33795918-43076339-AA04-4412-988F-7CEAF1D4154DQ34058079-7A5562C1-4BE6-4A3A-A399-910E50DF4926Q34074439-E022DDFF-233C-4A08-9B0E-2267D15A80D8Q34076012-EB92C988-0F2D-4151-8F5A-732B2AA6284DQ34131332-BB77BC29-56A0-43E2-88D2-27CFA68B9035Q34255270-C68A363E-36CE-4318-A09A-52750031DA4FQ34333807-09E10B14-DB31-4C0F-AD7F-C8B361639588Q34375148-B3E1196B-2432-4575-8823-639568A7D85E
P2860
Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Semirational design of active ...... omain with enhanced stability.
@en
type
label
Semirational design of active ...... omain with enhanced stability.
@en
prefLabel
Semirational design of active ...... omain with enhanced stability.
@en
P2093
P2860
P356
P1476
Semirational design of active ...... omain with enhanced stability.
@en
P2093
P2860
P304
14675-14680
P356
10.1073/PNAS.95.25.14675
P407
P50
P577
1998-12-01T00:00:00Z