Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive
about
Evolution favors protein mutational robustness in sufficiently large populationsThermodynamic prediction of protein neutralityLessons from the lysozyme of phage T4Structural characterization of an engineered tandem repeat contrasts the importance of context and sequence in protein foldingComparison of family 12 glycoside hydrolases and recruited substitutions important for thermal stabilityTheHumicola griseaCel12A enzyme structure at 1.2 Å resolution and the impact of its free cysteine residues on thermal stabilityContributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozymeThe Impact of Introducing a Histidine into an Apolar Cavity Site on Docking and Ligand RecognitionRecent advances in our understanding of protein conformational stability from a pharmaceutical perspective.A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase.Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme.In vitro evolution of thermostable p53 variantsA test of the relationship between sequence and structure in proteins: excision of the heme binding site in apocytochrome b5.Positive and negative design in stability and thermal adaptation of natural proteinsHow protein stability and new functions trade offA test of the "jigsaw puzzle" model for protein folding by multiple methionine substitutions within the core of T4 lysozyme.Inferring stabilizing mutations from protein phylogenies: application to influenza hemagglutinin.Automated electron-density sampling reveals widespread conformational polymorphism in proteinsNanohedra: using symmetry to design self assembling protein cages, layers, crystals, and filaments.Interdomain communication revealed in the diabetes drug target mitoNEETStrand swapping regulates the iron-sulfur cluster in the diabetes drug target mitoNEETDelineation of an evolutionary salvage pathway by compensatory mutations of a defective lysozyme.Increasing protein stability by altering long-range coulombic interactions.Protein thermostability above 100 degreesC: a key role for ionic interactions.From protein engineering to immobilization: promising strategies for the upgrade of industrial enzymesSemirational design of active tumor suppressor p53 DNA binding domain with enhanced stability.Non-additive stabilization by halogenated amino acids reveals protein plasticity on a sub-angstrom scale.Improvement of Lead Tolerance of Saccharomyces cerevisiae by Random Mutagenesis of Transcription Regulator SPT3.Context-dependent protein stabilization by methionine-to-leucine substitution shown in T4 lysozyme.Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites.Fundamental processes of protein folding: measuring the energetic balance between helix formation and hydrophobic interactions.Adaptive HIV-1 evolutionary trajectories are constrained by protein stability.Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2.Directed evolution of a thermostable phosphite dehydrogenase for NAD(P)H regeneration.Directed evolution of beta -glucosidase A from Paenibacillus polymyxa to thermal resistance.Contribution of engineered electrostatic interactions to the stability of cytosolic malate dehydrogenase.A cross-section of the fitness landscape of dihydrofolate reductase.Additivity of differential conformational dynamics in hyperthermophile/mesophile rubredoxin chimeras as monitored by hydrogen exchange.Increased thermal resistance and modification of the catalytic properties of a beta-glucosidase by random mutagenesis and in vitro recombination.Amino-Acid Network Clique Analysis of Protein Mutation Non-Additive Effects: A Case Study of Lysozme.
P2860
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P2860
Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive
description
1995 nî lūn-bûn
@nan
1995 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Enhancement of protein stabili ...... ons in T4 lysozyme is additive
@ast
Enhancement of protein stabili ...... ons in T4 lysozyme is additive
@en
Enhancement of protein stabili ...... ons in T4 lysozyme is additive
@nl
type
label
Enhancement of protein stabili ...... ons in T4 lysozyme is additive
@ast
Enhancement of protein stabili ...... ons in T4 lysozyme is additive
@en
Enhancement of protein stabili ...... ons in T4 lysozyme is additive
@nl
prefLabel
Enhancement of protein stabili ...... ons in T4 lysozyme is additive
@ast
Enhancement of protein stabili ...... ons in T4 lysozyme is additive
@en
Enhancement of protein stabili ...... ons in T4 lysozyme is additive
@nl
P2093
P356
P1476
Enhancement of protein stabili ...... ons in T4 lysozyme is additive
@en
P2093
B K Shoichet
B W Matthews
K P Wilson
P304
P356
10.1093/PROTEIN/8.10.1017
P577
1995-10-01T00:00:00Z