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Dependence of antibody-mediated presentation of antigen on FcRn

Dependence of antibody-mediated presentation of antigen on FcRn

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Immunoglobulin Transporting Receptors Are Potential Targets for the Immunity Enhancement and Generation of Mammary Gland Bioreactor Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics Cross-presentation of IgG-containing immune complexes The Role of FcRn in Antigen Presentation Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics Optimizing pH Response of Affinity between Protein G and IgG Fc: HOW ELECTROSTATIC MODULATIONS AFFECT PROTEIN-PROTEIN INTERACTIONS Targeting FcRn for the modulation of antibody dynamics Is infant immunization by breastfeeding possible?Neonatal Fc receptor and IgG-based therapeutics The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells FcRn overexpression in transgenic mice results in augmented APC activity and robust immune response with increased diversity of induced antibodies Characterization of the rabbit neonatal Fc receptor (FcRn) and analyzing the immunophenotype of the transgenic rabbits that overexpresses FcRn Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules.The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity.The effect of pH dependence of antibody-antigen interactions on subcellular trafficking dynamics.Antibody-dependent transplacental transfer of malaria blood-stage antigen using a human ex vivo placental perfusion model.Monoclonal antibodies: versatile platforms for cancer immunotherapy.Neonatal Fc receptor: from immunity to therapeutics IgG subclasses and allotypes: from structure to effector functions.Selection of nanobodies that target human neonatal Fc receptor.Extending half-life by indirect targeting of the neonatal Fc receptor (FcRn) using a minimal albumin binding domain.Bovine FcRn-mediated human immunoglobulin G transfer across the milk-blood barrier in transgenic mice.Regulation of immune responses by the neonatal fc receptor and its therapeutic implications FcRn overexpression in mice results in potent humoral response against weakly immunogenic antigen.Transgenic rabbits that overexpress the neonatal Fc receptor (FcRn) generate higher quantities and improved qualities of anti-thymocyte globulin (ATG).Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells.A neonatal Fc receptor-targeted mucosal vaccine strategy effectively induces HIV-1 antigen-specific immunity to genital infection.Fully human monoclonal antibody inhibitors of the neonatal fc receptor reduce circulating IgG in non-human primates.Recent advances using FcRn overexpression in transgenic animals to overcome impediments of standard antibody technologies to improve the generation of specific antibodies.FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes.Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics.FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin.Analysis of Response Elements Involved in the Regulation of the Human Neonatal Fc Receptor Gene (FCGRT).Overexpression of Bovine FcRn in Mice Enhances T-Dependent Immune Responses by Amplifying T Helper Cell Frequency and Germinal Center Enlargement in the Spleen.MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life Mucosal antibodies in the regulation of tolerance and allergy to foods.The immunologic functions of the neonatal Fc receptor for IgG Antibodies to gp120 and PD-1 expression on virus-specific CD8+ T cells in protection from simian AIDS Biodistribution Analyses of a Near-Infrared, Fluorescently Labeled, Bispecific Monoclonal Antibody Using Optical Imaging

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Dependence of antibody-mediated presentation of antigen on FcRn

http://www.wikidata.org/entity/Q36756942

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2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Dependence of antibody-mediated presentation of antigen on FcRn

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Dependence of antibody-mediated presentation of antigen on FcRn

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Dependence of antibody-mediated presentation of antigen on FcRn

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PNAS.0801717105

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Proceedings of the National Academy of Sciences of the United States of America

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Dependence of antibody-mediated presentation of antigen on FcRn

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Derry C Roopenian

http://www.w3.org/2001/XMLSchema#string

Edgar Milford

http://www.w3.org/2001/XMLSchema#string

Finn-Eirik Johansen

http://www.w3.org/2001/XMLSchema#string

Jan Terje Andersen

http://www.w3.org/2001/XMLSchema#string

Kanna Kobayashi

http://www.w3.org/2001/XMLSchema#string

Ludvig M Sollid

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Richard S Blumberg

http://www.w3.org/2001/XMLSchema#string

Shuo-Wang Qiao

http://www.w3.org/2001/XMLSchema#string

Wayne I Lencer

http://www.w3.org/2001/XMLSchema#string

P2860

MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells

The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan

Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation

IgEb immune complexes activate macrophages through FcgammaRIV binding

An Fc receptor structurally related to MHC class I antigens

IgG Fc receptors

pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat.

Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies.

Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn.

Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria

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9337-9342

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scholarly article

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10.1073/PNAS.0801717105

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27

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105

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2008-07-01T00:00:00Z

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5252832

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18599440

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2453734

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