Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells.
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Targeting histone methyltransferases and demethylases in clinical trials for cancer therapyEpigenetics in breast cancer: what's new?Protein lysine acetylation by p300/CBPKDM1 class flavin-dependent protein lysine demethylasesBase excision repair facilitates a functional relationship between Guanine oxidation and histone demethylationHistone lysine demethylases in breast cancer.Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models.High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients.Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats.Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitorsCoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer.Microarray gene expression profiling reveals potential mechanisms of tumor suppression by the class I HDAC-selective benzoylhydrazide inhibitors.Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448Epigenetic mechanisms in commonly occurring cancers.Genome-Wide Analysis Reveals Selective Modulation of microRNAs and mRNAs by Histone Deacetylase Inhibitor in B Cells Induced to Undergo Class-Switch DNA Recombination and Plasma Cell Differentiation.Epigenetics as a therapeutic target in breast cancer.Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells.The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer.Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.Tamoxifen Action in ER-Negative Breast Cancer.Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells.The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell linesEpigenetic regulation of LSD1 during mammary carcinogenesis.The long non-coding RNA EPB41L4A-AS2 inhibits tumor proliferation and is associated with favorable prognoses in breast cancer and other solid tumors.Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance.Reexpression of tumor suppressor, sFRP1, leads to antitumor synergy of combined HDAC and methyltransferase inhibitors in chemoresistant cancers.LincRNAFEZF1-AS1 represses p21 expression to promote gastric cancer proliferation through LSD1-Mediated H3K4me2 demethylation.Epigenetic reprogramming in breast cancer: from new targets to new therapies.Functional interaction of histone deacetylase 5 (HDAC5) and lysine-specific demethylase 1 (LSD1) promotes breast cancer progression.LSD1 inhibitors: a patent review (2010-2015).The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma.Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells.Epigenetic therapy approaches in non-small cell lung cancer: Update and perspectives.The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma.Histone Lysine Demethylase Inhibitors.Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases.A comprehensive review of lysine-specific demethylase 1 and its roles in cancer.An epigenetic switch regulates de novo DNA methylation at a subset of pluripotency gene enhancers during embryonic stem cell differentiation.Silencing of LSD1 gene modulates histone methylation and acetylation and induces the apoptosis of JeKo-1 and MOLT-4 cells.Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells.
P2860
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P2860
Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Inhibitors of histone demethyl ...... in human breast cancer cells.
@ast
Inhibitors of histone demethyl ...... in human breast cancer cells.
@en
type
label
Inhibitors of histone demethyl ...... in human breast cancer cells.
@ast
Inhibitors of histone demethyl ...... in human breast cancer cells.
@en
prefLabel
Inhibitors of histone demethyl ...... in human breast cancer cells.
@ast
Inhibitors of histone demethyl ...... in human breast cancer cells.
@en
P2093
P2860
P1476
Inhibitors of histone demethyl ...... in human breast cancer cells.
@en
P2093
Lamia Boric
Nancy E Davidson
Patrick G Shaw
Shauna N Vasilatos
P2860
P2888
P304
P356
10.1007/S10549-011-1480-8
P407
P577
2011-03-31T00:00:00Z