Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance.
about
Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV.Bacillus anthracis GrlAV96A topoisomerase IV, a quinolone resistance mutation that does not affect the water-metal ion bridgeBypassing fluoroquinolone resistance with quinazolinediones: studies of drug-gyrase-DNA complexes having implications for drug design.Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae.Activity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions.Structure based in silico analysis of quinolone resistance in clinical isolates of Salmonella Typhi from India.Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase.Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones.Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.Mechanism of quinolone action and resistance.Safety issues and drug-drug interactions with commonly used quinolones.Topoisomerases: Resistance versus Sensitivity, How Far We Can Go?Molecular basis for the differential quinolone susceptibility of mycobacterial DNA gyrase.Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.Description of compensatory gyrA mutations restoring fluoroquinolone susceptibility in Mycobacterium tuberculosis.Insights into the mechanism of inhibition of novel bacterial topoisomerase inhibitors from characterization of resistant mutants of Staphylococcus aureus.Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance.Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities.Fluoroquinolone-Gyrase-DNA Cleaved Complexes.Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase.A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.Antimicrobial resistance (AMR) nanomachines-mechanisms for fluoroquinolone and glycopeptide recognition, efflux and/or deactivation.The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery.Esterase-Catalyzed Siderophore Hydrolysis Activates an Enterobactin-Ciprofloxacin Conjugate and Confers Targeted Antibacterial Activity.Phenotypic and genotypic detection of antibiotic resistance of Pseudomonas aeruginosa isolated from urinary tract infections.Antibacterial and Pharmacological Evaluation of Fluoroquinolones: A Chemoinformatics ApproachSynthesis and Antibacterial Activity of Some Novel 4-Oxopyrido[2,3-a]phenothiazines
P2860
Q33556083-29D99A5B-5BE0-42D2-B323-3FC7564152EEQ34119765-D569B7CF-C916-45C0-88B8-6E4431B5F804Q34597404-2A584620-7525-4486-9828-4E372139FE34Q34756857-36239672-A61C-4F4E-8C72-B5F5ABAE09A2Q35076809-7EE26ECD-7AD9-4EB4-8AEF-F60FE8FBC930Q35592636-2896780D-5ED6-4B71-AEB1-C72519F81177Q35626961-63108B58-18D3-4945-B38F-0C0B10E72723Q35848139-ECDA1065-3D39-4461-B1FC-52990F252065Q36607348-CEE100F9-1C8D-4F4E-9F8E-2F9C607FD7C9Q36607637-42D8ACBA-D5F5-48A5-950B-E4B9339DBEBBQ36817994-8A5CB22D-2D33-405D-8FD1-5D3403DBF49FQ37407949-4F203010-43DD-4726-A179-B35115299B96Q37701591-2DE3D2B3-CAEF-40CA-9692-10F25E387924Q38271318-E869E07A-EF51-4261-8833-9F1F60927EF6Q38968355-09F33A0E-91B5-4CC0-B063-A120C0750A4AQ39683413-CFC370C3-3EA5-49F8-A110-2BD889B2B33CQ40239631-65B06F0F-4992-4721-A9AB-C0A95343A979Q40656048-D2761C07-6B7C-409F-AF64-CCB5F2766ACEQ40833065-4D564A9F-EA19-4C86-B657-A59B5D916437Q41120230-267C3FFF-81BC-4688-B844-CA8A3BEBE090Q46335874-6985233F-B178-46D3-A3CD-F833FCDCAE32Q47101582-DECFDC87-75C4-4F43-BA69-6726A9BB745CQ49607576-56DF683D-E734-4BCC-80B8-1501389D7CBDQ52319877-BF06B567-025A-4223-9EEE-F334704BA8E2Q52355825-E072EBFF-BF33-4FD0-9CBF-373ED9E16EAFQ52360303-E701E7E1-3491-4BE1-B16C-BA1DD55DADD3Q52656083-247D23C2-7CC0-41CD-AE58-1FF5DC9F51D5Q53762102-1A6D53FF-7E43-4468-85B0-823DEB1B7DFAQ55417089-6DCF2EED-7D5F-4CBE-AA66-3BE967996981Q57494445-1C10A929-B179-4923-99BB-ADA0EA59765BQ57787870-E7BFAE69-2873-4962-AC30-4F397F91E464
P2860
Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Topoisomerase IV-quinolone int ...... basis of quinolone resistance.
@en
type
label
Topoisomerase IV-quinolone int ...... basis of quinolone resistance.
@en
prefLabel
Topoisomerase IV-quinolone int ...... basis of quinolone resistance.
@en
P2093
P2860
P356
P1476
Topoisomerase IV-quinolone int ...... basis of quinolone resistance.
@en
P2093
Charles L Turnbough
Katie J Aldred
Neil Osheroff
Robert J Kerns
Sylvia A McPherson
P2860
P304
P356
10.1093/NAR/GKT124
P407
P577
2013-03-04T00:00:00Z