Growth factor induction by the adenovirus type 5 E1A 12S protein is required for immortalization of primary epithelial cells.

Growth factor induction by the adenovirus type 5 E1A 12S protein is required for immortalization of primary epithelial cells.

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http://www.wikidata.org/entity/Q36792724
A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasisA mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressorUse of adenoviral E1A protein to analyze K18 promoter deregulation in colon carcinoma cells discloses a role for CtBP1 and BRCA1.An improved genetic system for detection and analysis of protein nuclear import signals.Physical and functional interactions between the corepressor CtBP and the Epstein-Barr virus nuclear antigen EBNA3CRetinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis.Expression of the pRb-binding regions of E1A enables efficient transformation of primary epithelial cells by v-src.Induction of gene expression by exon 2 of the major E1A proteins of adenovirus type 5.The amino-terminal portion of CD1 of the adenovirus E1A proteins is required to induce susceptibility to tumor necrosis factor cytolysis in adenovirus-infected mouse cellsThe C-terminal region of E1A: a molecular tool for cellular cartography.Identification of genes involved in epithelial-mesenchymal transition and tumor progression.The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains.Immortalization of primary epithelial cells requires first- and second-exon functions of adenovirus type 5 12S.Acetylation of the adenovirus-transforming protein E1A determines nuclear localization by disrupting association with importin-alpha.Rac regulates the stability of the adherens junction and its components, thus affecting epithelial cell differentiation and transformation.
P2860

Growth factor induction by the adenovirus type 5 E1A 12S protein is required for immortalization of primary epithelial cells.

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http://www.wikidata.org/entity/Q36792724
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1988 nî lūn-bûn
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1988年の論文
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1988年論文
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1988年論文
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1988年論文
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1988年論文
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1988年論文
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1988年论文
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1988年论文
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name
Growth factor induction by the ...... n of primary epithelial cells.
@ast
Growth factor induction by the ...... n of primary epithelial cells.
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type
label
Growth factor induction by the ...... n of primary epithelial cells.
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Growth factor induction by the ...... n of primary epithelial cells.
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prefLabel
Growth factor induction by the ...... n of primary epithelial cells.
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Growth factor induction by the ...... n of primary epithelial cells.
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P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
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P921
P932
P356
P1433
P1476
Growth factor induction by the ...... n of primary epithelial cells.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P921
P932