mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer.
about
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptideCCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1S6K1 plays a critical role in early adipocyte differentiationDeregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimusNext-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategySestrins at the crossroad between stress and agingRegulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylationRegulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane TargetingRapalogs in cancer prevention: anti-aging or anticancer?Translational control mechanisms in metabolic regulation: critical role of RNA binding proteins, microRNAs, and cytoplasmic RNA granulesThe pathogenic role of persistent milk signaling in mTORC1- and milk-microRNA-driven type 2 diabetes mellitusGlycogen synthase kinase-3 inhibition enhances translation of pluripotency-associated transcription factors to contribute to maintenance of mouse embryonic stem cell self-renewalMutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin ResistanceStructural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop PhosphorylationStructural Basis for the Association of the Redox-sensitive Target of Rapamycin FATC Domain with Membrane-mimetic MicellesSestrins inhibit mTORC1 kinase activation through the GATOR complexExcessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand Early Childhood ObesityComputational modeling and analysis of insulin induced eukaryotic translation initiationS6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage responseSuppression of replicative senescence by rapamycin in rodent embryonic cellsMelatonin-mediated insulin synthesis during endoplasmic reticulum stress involves HuD expression in rat insulinoma INS-1E cellsLeucine signaling in the pathogenesis of type 2 diabetes and obesityActivation of a metabolic gene regulatory network downstream of mTOR complex 1cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.Molecular characterization of preneoplastic lesions provides insight on the development of renal tumors.The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in DrosophilaLeucyl-tRNA synthetase regulates lactation and cell proliferation via mTOR signaling in dairy cow mammary epithelial cellsA novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesisDynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling.Impact of diabetes mellitus on the outcome of pancreatic cancer.Activation of the AMP-activated protein kinase-p38 MAP kinase pathway mediates apoptosis induced by conjugated linoleic acid in p53-mutant mouse mammary tumor cells.Ribosomal protein S6 kinase is a critical downstream effector of the target of rapamycin complex 1 for long-term facilitation in Aplysia.Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinaseMaternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in miceGenetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study.Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulationIGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects.Glycogen synthase kinase 3beta activation is a prerequisite signal for cytokine production and chemotaxis in human mast cellsProton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.Switch in signaling control of mTORC1 activity after oncoprotein expression in thyroid cancer cell lines.
P2860
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P2860
mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer.
@en
type
label
mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer.
@en
prefLabel
mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer.
@en
P2093
P1476
mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer.
@en
P2093
Anand Selvaraj
George Thomas
Stephen G Dann
P304
P356
10.1016/J.MOLMED.2007.04.002
P577
2007-04-23T00:00:00Z