A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. - Wikidata - wikimedia - TriplyDB

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

http://www.wikidata.org/entity/Q36802757

about

The role for protein tyrosine phosphatase non-receptor type 22 in regulating intestinal homeostasis B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling Restoring the balance: immunotherapeutic combinations for autoimmune disease Type I interferon in the pathogenesis of lupus.Altered B cell signalling in autoimmunity.B cells and type 1 diabetes ...in mice and men.Protein tyrosine phosphatases as potential therapeutic targets.Advances in lupus genetics and epigenetics The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes.Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen.Role of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammation PTPN22: the archetypal non-HLA autoimmunity gene.Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice.Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome.Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort The genetics of human autoimmune disease: A perspective on progress in the field and future directions.Use of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytes B-cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome.BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells.Negative regulation of TLR signaling in myeloid cells--implications for autoimmune diseases.The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development.Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways.IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity.B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes.Autoimmune Variant PTPN22 C1858T Is Associated With Impaired Responses to Influenza Vaccination.Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells.Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22 PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection.PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil Activation Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.Memory CD8+ T cells exhibit increased antigen threshold requirements for recall proliferation PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations.

P2860

Q26741130-8EC9EDE3-2665-4D1E-A3B1-2845D74A753B Q26996644-B4A3E610-5CB3-4FFB-9DF3-370726A4C346 Q28081321-B1E24A26-C8AF-4D1B-B612-4AD57C99BA70 Q33423646-BB2EB4E9-BBBD-4575-8DFE-7397E06E6C5A Q33555986-DF238819-F72D-4463-8BF9-98617228EB13 Q33852174-208ED6A5-029E-4912-85C7-3895050C18B1 Q33924642-7CEA5518-A911-4509-9EE7-EF338A800A6A Q33926306-63A21EF6-695A-4494-A23F-73930C8B78AC Q34295063-8B05649C-159E-4701-A734-E68482B71987 Q34464114-67B0B3B1-BF01-4AA2-B774-BBBDFA4C7243 Q34918378-75582AD2-B2BA-4BEC-B8CD-7A334CDB0CF0 Q34946314-78348DC2-CCF9-434C-B815-29217D24DA29 Q35071862-3DAADE84-B607-4368-AF01-26DBEAC74685 Q35085007-E146CCD9-9627-42DB-A312-5DD11467702C Q35221741-2F73FFA0-D7CA-422B-BF8F-B402AB686935 Q35567857-C0C1E2F1-6194-4B9D-8695-4A3B6EF6231A Q36010142-38716777-1E9F-4809-BF09-10FBF42935D6 Q36080732-914502EC-DA1B-48E2-9EF5-EE13B55CC495 Q36088790-06829E21-1B06-402D-B904-56FB7E6DEE8B Q36236745-4FEC08C7-DB12-4464-95ED-94C662297EEA Q36355094-C7D74B1E-95A7-45B4-B25D-B08E4EBF9C6E Q36371940-15E90412-3108-46EA-A097-BB34E9220A23 Q36372629-BB20E32D-C3A0-4C86-A934-7876B863D524 Q36437284-8135FDDF-A940-4263-A33D-3AAF6910252E Q36485370-215D7ED2-4112-45D6-BDE7-708C7114DE6F Q36793513-B81D45E9-72EA-4CC2-A5D5-78B87E7EBA32 Q36863144-03F6C474-871A-4EE8-B67B-2528CF3B0A29 Q36863150-39E04A48-24EF-4931-BF57-688DD6E5C3B5 Q36867370-AE0B359F-F025-4BBA-B356-F025CA303DE8 Q36995345-75195EF6-D680-4958-81A0-EEB729FB9452 Q37033053-BBA049B5-F97C-4B0E-8741-CF231CEF0B62 Q37063297-9D93F893-46C1-40FC-A30B-296F8872C054 Q37066101-FCCD9197-B21D-485B-B78A-EF4027A126B5 Q37088189-99DFB4AA-BCC1-47C3-AD8A-90629A87765F Q37469344-C9167713-F288-4ABD-B8BC-021EBA47BDD1 Q37471088-7E00D213-B8AC-4927-B518-D9BC42BAD1B5 Q37548431-FC878EE0-FC33-400D-90EE-C15C90D19DB0 Q37576718-49F9DD6F-7A08-4C73-907E-F1DFFA7357B7 Q37600124-8BE50757-AF84-4DDF-A28D-0EA806F7E3C8 Q37645635-D9C182F0-DE0A-4809-AF85-CB5C4A8DC53C

P2860

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

http://www.wikidata.org/entity/Q36802757

description

2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

@ast

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

@en

type

label

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

@ast

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

@en

prefLabel

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

@ast

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

@en

P1433

Q36802757-E15E1CCC-2EA5-4F3C-84EF-E4722CF550AF

P1476

Q36802757-C9D10FE7-2F35-43A8-8D8D-91B89B7E04AA

P2093

Q36802757-180F8F63-1D73-4C74-9DFE-AE757FF51ED0

Q36802757-1D6DB44F-4216-4F30-AA93-EFB7FBF3645A

Q36802757-2909324A-1227-4D30-A60A-520D7F10DD40

Q36802757-29885C82-F7CA-4CF1-B1AD-1888A6EAB0D3

Q36802757-5975F06C-8636-4BCE-9AD6-AE1CD0E36853

Q36802757-6DE86293-5116-4B98-B1C4-53BFDB3B9BDD

Q36802757-76E61ED2-998F-477C-9417-63E631827271

Q36802757-91D0BA97-CE64-497F-965E-8F4637E586AF

Q36802757-9E1A8113-D21D-4B86-BAC6-FDA1055CE45E

Q36802757-A09E6F92-B840-44F8-97FD-74BD76C18A92

P2860

Q36802757-01A25550-92EC-46E3-8E7B-141A2D4DF8D0

Q36802757-045992ED-3415-417E-A5CE-401E35BF433A

Q36802757-0B1A5AF4-86AF-4EA7-BFB8-4DEB5D710E9E

Q36802757-16445ACC-0170-4813-85EC-94B706CD6E21

Q36802757-1DF7E272-7DDA-45E1-91BC-06EF4A1D6E0C

Q36802757-1E1D5BD2-DDC2-4F19-9F22-AB1D64FC19C7

Q36802757-24FEAF17-F8AB-4797-AFB8-0120A15EB685

Q36802757-2A17D56B-09C3-4FD0-9884-CD8F47FC4581

Q36802757-3533A843-412E-49E5-B5BF-765D4D87C8B2

Q36802757-409A134B-305A-488E-9A04-292E0BC1B2A9

P304

Q36802757-2AD9F487-BC04-4378-A5E9-E7B6F281A59D

P31

Q36802757-263AB573-71A0-4D69-B45C-2BDA5FAB6AF3

P356

Q36802757-A0052261-4926-4EB0-B7E1-43F305DC7B24

P407

Q36802757-C6094BEC-0476-41C6-AEEE-083FC8402B75

P433

Q36802757-AE68D729-1B40-4B82-9B37-A668C3C9377E

P478

Q36802757-6DC0FE24-2AE8-4435-8948-C96912815915

P577

Q36802757-EA6DC014-D264-48CC-B652-D82DB61639CE

P5875

Q36802757-5960F255-F6F1-4BC0-AC09-A9A3A5879E4D

P698

Q36802757-353F79B1-F719-47AE-9EC2-9E07CC49D097

P932

Q36802757-15EFE071-F942-4368-9BAF-554C28A0563C

P356

P1433

Journal of Clinical Investigation

P1476

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

@en

P2093

Alejandro Wolf-Yadlin

http://www.w3.org/2001/XMLSchema#string

David J Rawlings

http://www.w3.org/2001/XMLSchema#string

Denny Liggitt

http://www.w3.org/2001/XMLSchema#string

Jane H Buckner

http://www.w3.org/2001/XMLSchema#string

Randall T Moon

http://www.w3.org/2001/XMLSchema#string

Richard G James

http://www.w3.org/2001/XMLSchema#string

Shaun Jackson

http://www.w3.org/2001/XMLSchema#string

Socheath Khim

http://www.w3.org/2001/XMLSchema#string

Swati Singh

http://www.w3.org/2001/XMLSchema#string

Tania Habib

http://www.w3.org/2001/XMLSchema#string

P2860

Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp

Identification of substrates of human protein-tyrosine phosphatase PTPN22

Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate

Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

Role of PTPN22 in type 1 diabetes and other autoimmune diseases

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

P304

2024-2036

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1172/JCI66963

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

123

http://www.w3.org/2001/XMLSchema#string

P577

2013-04-24T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

236338501

http://www.w3.org/2001/XMLSchema#string

P698

23619366

http://www.w3.org/2001/XMLSchema#string

P932

3638909

http://www.w3.org/2001/XMLSchema#string