A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency
about
The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia.Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection.Spontaneous reactivation of herpes simplex virus type 1 in latently infected murine sensory gangliaA comparison of herpes simplex virus type 1 and varicella-zoster virus latency and reactivationThe molecular basis of herpes simplex virus latencyOcular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated?Restarting Lytic Gene Transcription at the Onset of Herpes Simplex Virus ReactivationHerpes Simplex Virus and Interferon Signaling Induce Novel Autophagic Clusters in Sensory NeuronsIdentification of a novel latency-specific splice donor signal within the herpes simplex virus type 1 2.0-kilobase latency-associated transcript (LAT): translation inhibition of LAT open reading frames by the intron within the 2.0-kilobase LAT.Role of chromatin during herpesvirus infections.De novo synthesis of VP16 coordinates the exit from HSV latency in vivo.Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice.A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivationLatency-associated transcripts in corneas and ganglia of HSV-1 infected rabbitsEpigenetic regulation of latent HSV-1 gene expression.A 2.9-kilobase noncoding nuclear RNA functions in the establishment of persistent Hz-1 viral infection.The quantity of latent viral DNA correlates with the relative rates at which herpes simplex virus types 1 and 2 cause recurrent genital herpes outbreaks.The latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits.Evidence for a bidirectional element located downstream from the herpes simplex virus type 1 latency-associated promoter that increases its activity during latencyOptimized viral dose and transient immunosuppression enable herpes simplex virus ICP0-null mutants To establish wild-type levels of latency in vivo.Analysis of protein expression from within the region encoding the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1Enhancer and long-term expression functions of herpes simplex virus type 1 latency-associated promoter are both located in the same regionThree herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits.Herpes simplex virus type 1 2-kilobase latency-associated transcript intron associates with ribosomal proteins and splicing factors.Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.A herpes simplex virus type 1 mutant expressing a baculovirus inhibitor of apoptosis gene in place of latency-associated transcript has a wild-type reactivation phenotype in the mouse.Structural and kinetic analyses of herpes simplex virus type 1 latency-associated transcripts in human trigeminal ganglia and in cell cultureCellular FLIP can substitute for the herpes simplex virus type 1 latency-associated transcript gene to support a wild-type virus reactivation phenotype in mice.A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levelsNeither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virusDeacetylation of the herpes simplex virus type 1 latency-associated transcript (LAT) enhancer and a decrease in LAT abundance precede an increase in ICP0 transcriptional permissiveness at early times postexplant.Regions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo.Varicella-zoster virus open reading frame 21, which is expressed during latency, is essential for virus replication but dispensable for establishment of latencyHuman herpesviruses in the cornea.In vivo disruption of latent HSV by designer endonuclease therapyStable cell lines expressing high levels of the herpes simplex virus type 1 LAT are refractory to caspase 3 activation and DNA laddering following cold shock induced apoptosisTegument protein control of latent herpesvirus establishment and animation.In vivo replication of an ICP34.5 second-site suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation.Patterns of accumulation of miRNAs encoded by herpes simplex virus during productive infection, latency, and on reactivation.Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters.
P2860
Q24523533-5DCCB799-D8E8-48E9-888D-F603472FE708Q24535042-466FE9A3-D2E0-4157-9493-46582BC08E66Q24671732-F5FE0A2A-7B89-449E-B87A-B5CD015921D6Q26996418-2EEA356D-DB24-4880-801B-7B17DA1CAC4CQ27001272-91DCDCEA-8D3A-47F0-8D84-99FC599DB37BQ27021069-757617D4-C9E0-4D63-966A-FFC9D3169511Q30275510-A5927CF3-3CF7-42A5-B8DC-E8B7470878ABQ30744548-93C8093F-B362-4F11-B5F7-3D2CD105A44FQ33238462-235C35A2-7364-4666-A9BB-82F840FC8B11Q33346968-34DC005C-B085-49A4-98A6-E1FFAB04E07DQ33422983-82AB8A6E-2948-427E-A968-B85652ECB311Q33604367-DAFFC229-206A-4F53-8D5C-7D5812137E44Q33640067-9B5C7EB8-91BB-424B-BB63-B20C35838FFEQ33649139-AE4AF9BA-B3F2-4604-B024-3A18D13CD111Q33729340-0AD48542-8C58-4A1C-8F3B-80496965E32EQ33782436-CD67E88D-F708-490D-AE35-36A4ABD8D028Q33783025-E467536F-8576-4B8E-A10E-D45BC6ECA9B9Q33797778-AA0EAEF6-2D29-4EE2-91EB-5F0524B7517BQ33802267-1A74BAAF-D36F-44D4-879C-FC6B335F7C55Q33806643-A238CCD0-71E1-4A85-8F2E-B4E2B1AEFFC4Q33838578-C00AAF58-CB58-4FBC-837E-04D39FFCB1E2Q33839884-10B096B2-6903-46A5-96F3-B30DCCF88F69Q33845198-FD17B3E6-A950-453C-A38A-348917974596Q33869971-603685F6-2CB3-4D46-A30C-BA2BDA782308Q33931502-212525D3-0281-4D9D-BD92-09CF8880A209Q33984275-A8879497-E738-4AE8-8624-116873F978CFQ34256311-C1B317B1-6767-420B-AA40-E9FE2C19E3CCQ34307385-939A0919-3198-46E1-8FD3-89E887C4A360Q34330385-A07C1EB0-6A8C-42B2-8C0A-ED52F4922562Q34338858-D7338A56-6913-4159-8C4C-D81603366D96Q34353449-2323CF9E-A319-4C68-A377-44B8BEF0FC4DQ34358232-585710F3-1FCD-4C05-9FDE-5B23BEFE758AQ34465757-F3C775DA-BFE1-46FA-B261-0E9B83518B6FQ34509064-6A05D383-42A0-457E-A424-9831B1EA5F48Q34540648-D699A61A-1699-4E31-96C0-17F7C50FFE38Q34668446-F41DC7BE-0B9C-4AB7-9DCF-F07C10526F12Q34712750-B2CAC985-268C-48A7-A6C6-4A400AD49CB1Q34858111-A3B70BE1-D8F4-49F4-BA49-5DC1285C8CEDQ34926456-DB523214-0D50-4CA3-BD18-523813E1439DQ34986080-78290553-534E-4028-8FF3-A34A495CA558
P2860
A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
A deletion mutant of the laten ...... t state with reduced frequency
@en
type
label
A deletion mutant of the laten ...... t state with reduced frequency
@en
prefLabel
A deletion mutant of the laten ...... t state with reduced frequency
@en
P2093
P2860
P1433
P1476
A deletion mutant of the laten ...... t state with reduced frequency
@en
P2093
C L Bogard
M Kosz-Vnenchak
P A Schaffer
P2860
P304
P407
P577
1989-07-01T00:00:00Z