Pathology-specific effects of the IKur/Ito/IK,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation.
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Ion Channels in the HeartRole for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytesPro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atriaExpression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation.Novel pharmacological targets for the rhythm control management of atrial fibrillation.Rate-dependent effects of vernakalant in the isolated non-remodeled canine left atria are primarily due to block of the sodium channel: comparison with ranolazine and dl-sotalolAtrial-selective prolongation of refractory period with AVE0118 is due principally to inhibition of sodium channel activity.In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesisIsolation of human atrial myocytes for simultaneous measurements of Ca2+ transients and membrane currentsK+ current changes account for the rate dependence of the action potential in the human atrial myocyte.Atrial-selective sodium channel block for the treatment of atrial fibrillation.Altered Excitation-Contraction Coupling in Human Chronic Atrial Fibrillation.Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation.Effects of IKur blocker MK-0448 on human right atrial action potentials from patients in sinus rhythm and in permanent atrial fibrillationNew developments in atrial antiarrhythmic drug therapy.Ultra-rapid delayed rectifier channels: molecular basis and therapeutic implications.Novel molecular targets for atrial fibrillation therapy.Atrial selectivity of antiarrhythmic drugs.Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia.Novel therapeutic targets in the management of atrial fibrillation.The positive frequency-dependent electrophysiological effects of the IKur inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation.Anti-arrhythmic strategies for atrial fibrillation: The role of computational modeling in discovery, development, and optimization.Mathematical simulations of ligand-gated and cell-type specific effects on the action potential of human atrium.Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation.Inhibition of platelet-derived growth factor-AB signaling prevents electromechanical remodeling of adult atrial myocytes that contact myofibroblasts.Neurogenic contraction induced by the antiarrhythmic compound, AVE 0118, in rat small mesenteric arteries.Benchmarking electrophysiological models of human atrial myocytesRevealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity.Pergolide block of the cloned Kv1.5 potassium channels.Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics.In Silico Assessment of Efficacy and Safety of IKur Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding.Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin.Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?Modelling variability in cardiac electrophysiology: a moment-matching approach.Cardiac Potassium Channels: Physiological Insights for Targeted Therapy.[New developments in the antiarrhythmic therapy of atrial fibrillation].Interaction of DPP10a with Kv4.3 channel complex results in a sustained current component of human transient outward current Ito.
P2860
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P2860
Pathology-specific effects of the IKur/Ito/IK,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Pathology-specific effects of ...... n chronic atrial fibrillation.
@en
type
label
Pathology-specific effects of ...... n chronic atrial fibrillation.
@en
prefLabel
Pathology-specific effects of ...... n chronic atrial fibrillation.
@en
P2093
P2860
P356
P1476
Pathology-specific effects of ...... n chronic atrial fibrillation.
@en
P2093
K Matschke
P2860
P304
P356
10.1038/BJP.2008.209
P407
P577
2008-06-09T00:00:00Z