Molecular cloning and characterization of NESP55, a novel chromogranin-like precursor of a peptide with 5-HT1B receptor antagonist activity.
about
Immunohistochemical expression of neuroendocrine secretory protein-55 (NESP-55) in pituitary adenomasA novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNASDiverse splicing mechanisms fuse the evolutionarily conserved bicistronic MOCS1A and MOCS1B open reading framesAn imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locusThe GNAS complex locus and human diseases associated with loss-of-function mutations or epimutations within this imprinted geneGNAS locus and pseudohypoparathyroidismXLalphas, the extra-long form of the alpha-subunit of the Gs G protein, is significantly longer than suspected, and so is its companion AlexImprinting of the G(s)alpha gene GNAS1 in the pathogenesis of acromegalyMaternal inheritance of the Gnas cluster mutation Ex1A-T affects size, implicating NESP55 in growthPaternal versus maternal transmission of a stimulatory G-protein alpha subunit knockout produces opposite effects on energy metabolismIdentification and characterization of novel chromogranin B-derived peptides from porcine chromaffin granules by liquid chromatography/electrospray tandem MS.Bidirectional imprinting of a single gene: GNAS1 encodes maternally, paternally, and biallelically derived proteinsImprinted Nesp55 influences behavioral reactivity to novel environmentsDNA sequence polymorphisms within the bovine guanine nucleotide-binding protein Gs subunit alpha (Gsα)-encoding (GNAS) genomic imprinting domain are associated with performance traitsVariable imprinting of the heterotrimeric G protein G(s) alpha-subunit within different segments of the nephron.Identification of a methylation imprint mark within the mouse Gnas locus.Deletion of the noncoding GNAS antisense transcript causes pseudohypoparathyroidism type Ib and biparental defects of GNAS methylation in cisThe role of GNAS and other imprinted genes in the development of obesity.Alternative transcripts and evidence of imprinting of GNAL on 18p11.2.Potent constitutive cyclic AMP-generating activity of XLαs implicates this imprinted GNAS product in the pathogenesis of McCune-Albright syndrome and fibrous dysplasia of bone.Pseudohypoparathyroidism: one gene, several syndromes.Gut hormones: emerging role in immune activation and inflammation.Effects of deficiency of the G protein Gsα on energy and glucose homeostasisTranscription driven somatic DNA methylation within the imprinted Gnas clusterRegulation of dorsal raphe nucleus function by serotonin autoreceptors: a behavioral perspectiveThe silence RNA keeps: cis mechanisms of RNA mediated epigenetic silencing in mammals.Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus.GNAS Spectrum of Disorders.Imprinting status of Galpha(s), NESP55, and XLalphas in cell cultures derived from human embryonic germ cells: GNAS imprinting in human embryonic germ cellsLoss of XLαs (extra-large αs) imprinting results in early postnatal hypoglycemia and lethality in a mouse model of pseudohypoparathyroidism Ib.Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells.Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.Paternally inherited gsα mutation impairs adipogenesis and potentiates a lean phenotype in vivo.Autosomal dominant pseudohypoparathyroidism type Ib is associated with a heterozygous microdeletion that likely disrupts a putative imprinting control element of GNAS.Non-Coding RNAs at the Gnas and Snrpn-Ube3a Imprinted Gene Loci and Their Involvement in Hereditary Disorders.Imprinting the Gnas locus.A cluster of oppositely imprinted transcripts at the Gnas locus in the distal imprinting region of mouse chromosome 2Lessons learned from the initial sequencing of the pig genome: comparative analysis of an 8 Mb region of pig chromosome 17.Exon expression profiling reveals stimulus-mediated exon use in neural cells.NESP55, a novel chromogranin-like peptide, is expressed in endocrine tumours of the pancreas and adrenal medulla but not in ileal carcinoids.
P2860
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P2860
Molecular cloning and characterization of NESP55, a novel chromogranin-like precursor of a peptide with 5-HT1B receptor antagonist activity.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Molecular cloning and characte ...... receptor antagonist activity.
@en
type
label
Molecular cloning and characte ...... receptor antagonist activity.
@en
prefLabel
Molecular cloning and characte ...... receptor antagonist activity.
@en
P2093
P2860
P356
P1476
Molecular cloning and characte ...... receptor antagonist activity.
@en
P2093
Fischer-Colbrie R
Hogue-Angeletti R
Lovisetti-Scamihorn P
Wolkersdorfer M
P2860
P304
11657-11662
P356
10.1074/JBC.272.17.11657
P407
P577
1997-04-01T00:00:00Z