Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
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A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreadingMolecular basis for oncohistone H3 recognition by SETD2 methyltransferaseMolecular architecture of polycomb repressive complexesIdentification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, SThe Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity.Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED.Chromatin and Epigenetics at the Forefront: Finding Clues among PeaksJarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation.Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas.The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.Polycomb repressive complex 2 in an autoinhibited state.Inhibitors of Protein Methyltransferases and Demethylases.Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG.Citrullination/Methylation Crosstalk on Histone H3 Regulates ER-Target Gene Transcription.Oncogenic Mechanisms of Histone H3 Mutations.The Histone Variant H3.3 in Transcriptional Regulation and Human Disease.H3K27 methylation: a promiscuous repressive chromatin mark.Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".Shaping the cellular landscape with Set2/SETD2 methylation.Structure of the PRC2 complex and application to drug discovery.Recent progress in developing selective inhibitors of protein methyltransferases.Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor.Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors.Developing EZH2-Targeted Therapy for Lung Cancer.Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene.Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila.Characterization of H3.3K36M as a tool to study H3K36 methylation in cancer cells.Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.Polycomb and Trithorax Group Genes in Drosophila.Computational characterization of substrate and product specificities, and functionality of S-adenosylmethionine binding pocket in histone lysine methyltransferases from Arabidopsis, rice and maize.Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available: SuppleHistone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity.Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription.Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4.DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation.Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA.Structure, mechanism, and regulation of polycomb repressive complex 2.
P2860
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P2860
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Structural basis of oncogenic ...... polycomb repressive complex 2.
@en
type
label
Structural basis of oncogenic ...... polycomb repressive complex 2.
@en
prefLabel
Structural basis of oncogenic ...... polycomb repressive complex 2.
@en
P2093
P2860
P50
P356
P1476
Structural basis of oncogenic ...... polycomb repressive complex 2.
@en
P2093
Cataldo Tarricone
Elizabeth Underwood
Lesley F Haire
Neil Justin
Philip A Walker
Shuyang Chen
Stephen R Martin
Valeria De Marco
Ying Zhang
P2860
P2888
P356
10.1038/NCOMMS11316
P407
P577
2016-04-28T00:00:00Z