YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase
about
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulationPleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domainDistinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domainsMolecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinaseSpecific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activationLocalization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating proteinSH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchangeSmall-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptorBiochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with HckHeregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptorFoxO1 mediates insulin-dependent regulation of hepatic VLDL production in miceJanus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferonsRecombinant human insulin receptor substrate-1 protein. Tyrosine phosphorylation and in vitro binding of insulin receptor kinaseStructural basis for inhibition of the insulin receptor by the adaptor protein Grb14Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analogIdentification of residues involved in v-Src substrate recognition by site-directed mutagenesis.Human biliverdin reductase-based peptides activate and inhibit glucose uptake through direct interaction with the kinase domain of insulin receptorRegulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.Autophosphorylation of the two C-terminal tyrosine residues Tyr1316 and Tyr1322 modulates the activity of the insulin receptor kinase in vitro.Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.Fast and sequence-specific palladium-mediated cross-coupling reaction identified from phage display.Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.Characterization of the endogenous insulin receptor-related receptor in neuroblastomas.Using bacteria to determine protein kinase specificity and predict target substratesSmall molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseasesAngiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology.Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance.Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobilitySubstitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expressionInsulin Receptor Substrate 1, the Hub Linking Follicle-stimulating Hormone to Phosphatidylinositol 3-Kinase ActivationIRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.Conformational snapshots of Tec kinases during signaling.A computational study of the phosphorylation mechanism of the insulin receptor tyrosine kinase.Insulin signaling meets mitochondria in metabolism.Probing the kinome in real time with fluorescent peptides.Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice.
P2860
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P2860
YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase
@en
type
label
YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase
@en
prefLabel
YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase
@en
P2093
P2860
P356
P1476
YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase
@en
P2093
M Chaudhuri
S Chatterjee
S E Shoelson
P2860
P304
P356
10.1073/PNAS.89.6.2027
P407
P577
1992-03-01T00:00:00Z