Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus
about
Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922)A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphatePersistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infectionVisualization of mouse neuronal ganglia infected by Herpes Simplex Virus 1 (HSV-1) using multimodal non-linear optical microscopyEfficacies of antiherpesvirus nucleosides against two strains of herpes simplex virus type 1 in Vero and human embryo lung fibroblast cellsIdentification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.Susceptibility to other antiherpes drugs of pathogenic variants of herpes simplex virus selected for resistance to acyclovirHuman thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2.Interactions of herpes simplex virus type 1 with ND10 and recruitment of PML to replication compartments.Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and managementNeither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virusIdentification, localization, and regulation of expression of the UL24 protein of herpes simplex virus type 1.ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus type 1-infected cellsPrediction and identification of herpes simplex virus 1-encoded microRNAs.The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerasesHerpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant.Mutation within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)guanine.A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives.Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virusReactivation of thymidine kinase-defective herpes simplex virus is enhanced by nucleosideA viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus.Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal gangliaThe extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication.Genetic characterization of the vaccinia virus DNA polymerase: cytosine arabinoside resistance requires a variable lesion conferring phosphonoacetate resistance in conjunction with an invariant mutation localized to the 3'-5' exonuclease domain.Genetic characterization of the vaccinia virus DNA polymerase: identification of point mutations conferring altered drug sensitivities and reduced fidelity.Structure-function studies of the herpes simplex virus type 1 DNA polymerase.A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell cultureEngineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition.Examination of the roles of transcription factor Sp1-binding sites and an octamer motif in trans induction of the herpes simplex virus thymidine kinase gene.Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene.Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus.Rapid detection of cytomegalovirus in clinical specimens by using biotinylated DNA probes and analysis of cross-reactivity with herpes simplex virus.Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.Mutations Inactivating Herpes Simplex Virus 1 MicroRNA miR-H2 Do Not Detectably Increase ICP0 Gene Expression in Infected Cultured Cells or Mouse Trigeminal Ganglia.Herpes simplex virus is equipped with RNA- and protein-based mechanisms to repress expression of ATRX, an effector of intrinsic immunity.The role of herpes simplex virus ICP27 in the regulation of UL24 gene expression by differential polyadenylationAccumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus.
P2860
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P2860
Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
1985年论文
@zh
1985年论文
@zh-cn
name
Sensitivity of arabinosyladeni ...... ns to the DNA polymerase locus
@en
type
label
Sensitivity of arabinosyladeni ...... ns to the DNA polymerase locus
@en
prefLabel
Sensitivity of arabinosyladeni ...... ns to the DNA polymerase locus
@en
P2093
P2860
P1433
P1476
Sensitivity of arabinosyladeni ...... ns to the DNA polymerase locus
@en
P2093
H E Fleming
L K Leslie
M J Retondo
P2860
P304
P407
P577
1985-02-01T00:00:00Z