Effects of PKA phosphorylation of cardiac troponin I and strong crossbridge on conformational transitions of the N-domain of cardiac troponin C in regulated thin filaments.
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Calcium induced regulation of skeletal troponin--computational insights from molecular dynamics simulationsTemperature-induced cardiac remodeling in fishStructural dynamics of troponin I during Ca2+-activation of cardiac thin filaments: a multi-site Förster resonance energy transfer studyStructural basis for the in situ Ca(2+) sensitization of cardiac troponin C by positive feedback from force-generating myosin cross-bridgesSmall molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytesThin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts.Protein Kinases as Drug Development Targets for Heart Disease TherapyFRET study of the structural and kinetic effects of PKC phosphomimetic cardiac troponin T mutants on thin filament regulation.Coupling of adjacent tropomyosins enhances cross-bridge-mediated cooperative activation in a markov model of the cardiac thin filament.Structural and kinetic effects of PAK3 phosphorylation mimic of cTnI(S151E) on the cTnC-cTnI interaction in the cardiac thin filamentIn situ time-resolved FRET reveals effects of sarcomere length on cardiac thin-filament activation.Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy.The dilated cardiomyopathy-causing mutation ACTC E361G in cardiac muscle myofibrils specifically abolishes modulation of Ca(2+) regulation by phosphorylation of troponin IMolecular dynamics simulations of the cardiac troponin complex performed with FRET distances as restraints.Structural dynamics of C-domain of cardiac troponin I protein in reconstituted thin filamentEnhanced Ca2+ binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges.Fluorescence Based Characterization of Calcium Sensitizer Action on the Troponin Complex.Functionally conservative substitutions at cardiac troponin I S43/45.Förster resonance energy transfer structural kinetic studies of cardiac thin filament deactivation.The myosin-activated thin filament regulatory state, M⁻-open: a link to hypertrophic cardiomyopathy (HCM).The Frank-Starling Law: a jigsaw of titin proportions.Kinetics of fast changing intramolecular distance distributions obtained by combined analysis of FRET efficiency kinetics and time-resolved FRET equilibrium measurements.N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle.Dynamic Equilibrium of Cardiac Troponin C's Hydrophobic Cleft and Its Modulation by Ca2+ Sensitizers and a Ca2+ Sensitivity Blunting Phosphomimic, cTnT(T204E).Functional communication between PKC-targeted cardiac troponin I phosphorylation sites.
P2860
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P2860
Effects of PKA phosphorylation of cardiac troponin I and strong crossbridge on conformational transitions of the N-domain of cardiac troponin C in regulated thin filaments.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Effects of PKA phosphorylation ...... C in regulated thin filaments.
@en
type
label
Effects of PKA phosphorylation ...... C in regulated thin filaments.
@en
prefLabel
Effects of PKA phosphorylation ...... C in regulated thin filaments.
@en
P2093
P2860
P356
P1433
P1476
Effects of PKA phosphorylation ...... C in regulated thin filaments.
@en
P2093
Herbert C Cheung
Jayant James Jayasundar
Wen-Ji Dong
P2860
P304
P356
10.1021/BI700574N
P407
P577
2007-08-03T00:00:00Z