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New insights into repeat instability: role of RNA•DNA hybridsDNA slip-outs cause RNA polymerase II arrest in vitro: potential implications for genetic instabilityUnderstanding the genetic and molecular pathogenesis of Friedreich's ataxia through animal and cellular modelsThe balancing act of DNA repeat expansionsExpansion, mosaicism and interruption: mechanisms of the CAG repeat mutation in spinocerebellar ataxia type 1GFP-based fluorescence assay for CAG repeat instability in cultured human cellsDiverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells.A novel approach to investigate tissue-specific trinucleotide repeat instability.Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosisR loops stimulate genetic instability of CTG.CAG repeats.Modulation of trinucleotide repeat instability by DNA polymerase β polymorphic variant R137Q.Gender and cell-type-specific effects of the transcription-coupled repair protein, ERCC6/CSB, on repeat expansion in a mouse model of the fragile X-related disordersTopoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells.Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.X inactivation plays a major role in the gender bias in somatic expansion in a mouse model of the fragile X-related disorders: implications for the mechanism of repeat expansion.Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeatsNucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instabilityDefining genetic factors that modulate intergenerational CAG repeat instability in Drosophila melanogasterDirect and inverted repeats elicit genetic instability by both exploiting and eluding DNA double-strand break repair systems in mycobacteria.Making sense of intratumor genetic heterogeneity: altered frequency of androgen receptor CAG repeat length variants in breast cancer tissues.Cockayne syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo.Environmental stress induces trinucleotide repeat mutagenesis in human cells.Repeat instability during DNA repair: Insights from model systemsInstability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesisSomatic expansion in mouse and human carriers of fragile X premutation alleles.Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks.Instability and chromatin structure of expanded trinucleotide repeatsBidirectional transcription of trinucleotide repeats: roles for excision repair.Inhibition of DNA synthesis facilitates expansion of low-complexity repeats: is strand slippage stimulated by transient local depletion of specific dNTPs?Tissue-dependent regulation of RNAP II dynamics: the missing link between transcription and trinucleotide repeat instability in diseases?Expanded complexity of unstable repeat diseases.The dual nature of mismatch repair as antimutator and mutator: for better or for worse.Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble.Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR.Convergent transcription through microsatellite repeat tracts induces cell death.Break-induced replication links microsatellite expansion to complex genome rearrangements.RNA biology of disease-associated microsatellite repeat expansions.Coupling transcriptional state to large-scale repeat expansions in yeast.A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA)n Repeats Associated with Friedreich's AtaxiaHuman AP endonuclease inefficiently removes abasic sites within G4 structures compared to duplex DNA.
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Transcription destabilizes triplet repeats
@en
type
label
Transcription destabilizes triplet repeats
@en
prefLabel
Transcription destabilizes triplet repeats
@en
P2093
P2860
P356
P1476
Transcription destabilizes triplet repeats
@en
P2093
John H Wilson
Leroy Hubert
P2860
P304
P356
10.1002/MC.20488
P577
2009-04-01T00:00:00Z