Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth.
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New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeuticsMechanisms of Hippo pathway regulationA dynamic interface between ubiquitylation and cAMP signalingYAP and TAZ: a nexus for Hippo signaling and beyondhMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnoverCompeting to coordinate cell fate decisions: the MST2-Raf-1 signaling deviceHippo Stabilises Its Adaptor Salvador by Antagonising the HECT Ubiquitin Ligase Herc4.In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRsSingle-Cell Co-expression Analysis Reveals Distinct Functional Modules, Co-regulation Mechanisms and Clinical Outcomes.DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT ProteinsDysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes.Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling.Hippo-YAP signaling pathway: A new paradigm for cancer therapy.One Hippo and many masters: differential regulation of the Hippo pathway in cancer.Mitochondrial AKAP1 supports mTOR pathway and tumor growth.Growth Inhibition Accompanied by MOB1 Upregulation in Human Acute Lymphoid Leukemia Cells by 3-Deazaneplanocin A.Down-regulation of LATS2 in non-small cell lung cancer promoted the growth and motility of cancer cells.Targeting the Hippo signalling pathway for cancer treatment.Structural basis for autoinhibition and its relief of MOB1 in the Hippo pathway.Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways.PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription.PRAJA is overexpressed in glioblastoma and contributes to neural precursor development.Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.Impact of kinase activating and inactivating patient mutations on binary PKA interactions.USP21 regulates Hippo pathway activity by mediating MARK protein turnover.praja2 regulates KSR1 stability and mitogenic signalingRegulation of the Hippo Signaling Pathway by Ubiquitin Modification.Counterregulation of cAMP-directed kinase activities controls ciliogenesis.Ubiquitin-Dependent Regulation of the Mammalian Hippo Pathway: Therapeutic Implications for Cancer.
P2860
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P2860
Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Proteolysis of MOB1 by the ubi ...... supports glioblastoma growth.
@en
type
label
Proteolysis of MOB1 by the ubi ...... supports glioblastoma growth.
@en
prefLabel
Proteolysis of MOB1 by the ubi ...... supports glioblastoma growth.
@en
P2093
P2860
P50
P356
P1476
Proteolysis of MOB1 by the ubi ...... d supports glioblastoma growth
@en
P2093
Adriana Gallo
Clelia Tiziana Storlazzi
Corrado Garbi
Laura Rinaldi
Luca Lignitto
Luigi Insabato
Maria A Oliva
Maria Sepe
Matteo Gramanzini
Max E Gottesman
P2860
P2888
P356
10.1038/NCOMMS2791
P407
P577
2013-01-01T00:00:00Z